Optochemical modulation of corneal cold nerve terminal impulse activity with a photochromic ion channel blocker
DENAQ enters guinea pig cold sensory nerve endings primarily through P2X channels in excised corneas. Subsequently, DENAQ decreases the spontaneous nerve terminal impulse activity upon light irradiation by modulating voltage-gated potassium (K<sub>V</sub>) channel activity. Furthermore, the cold-evoked blink reflex is modulated by light in DENAQ-treated eyes. Chemical photoswitches like DENAQ might be potential new treatments for ocular discomfort and pain in dry eye disease.
Authors
- Víctor Meseguer (ORCID: https://orcid.org/0000-0002-7686-6228)
- Enrique Velasco (ORCID: https://orcid.org/0000-0001-7299-0750)
- Almudena Íñigo‐Portugués (ORCID: https://orcid.org/0000-0003-4368-5495)
- Richard Krämer (ORCID: https://orcid.org/0000-0002-8755-9389)
- Fernando Aleixandre‐Carrera (ORCID: https://orcid.org/0000-0002-4739-5033)
- Juana Gallar (ORCID: https://orcid.org/0000-0002-3559-3649)
- Wan‐Chen Lin (ORCID: https://orcid.org/0000-0001-7842-3036)
- Carlos Belmonte (ORCID: https://orcid.org/0000-0001-6891-5942)
- Ariadna Díaz‐Tahoces (ORCID: https://orcid.org/0000-0003-1163-5987)
- David Ares‐Suárez (ORCID: https://orcid.org/0000-0002-9222-4268)
- M. Carmen Acosta (ORCID: https://orcid.org/0000-0002-1759-068X)
- Susana Quirce (ORCID: https://orcid.org/0000-0001-9977-357X)
Institutions
- Universitat de Miguel Hernández d'Elx (ES)
- Instituto de Neurociencias (ES)
- Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL) (ES)
- University of California, Berkeley (US)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-09-28
- DOI
- https://doi.org/10.1111/bph.70189
- Primary Topic
- Photoreceptor and optogenetics research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Generalitat Valenciana
- European Regional Development Fund
- Agencia Estatal de Investigación
- Conselleria de Cultura, Educación y Ciencia, Generalitat Valenciana