The Clinical Efficacy of Self-Designed Nuangong Zhitong Ling in Primary Dysmenorrhea of Cold Coagulation Syndrome

Objective: To investigate the clinical efficacy of the self-designed Nuangong Zhitong Ling in primary dysmenorrhea (PD) of cold coagulation syndrome. Methods: Forty patients with PD of cold coagulation syndrome who were treated with the self-designed Nuangong Zhitong Ling in our hospital from January 2023 to December 2024 were included in the study group. Another 40 patients with the same disease who were treated with ibuprofen sustained-release capsules during the same period were included in the control group. The clinical efficacy, pain conditions, temperature changes in the infrared thermal imaging regions of the two groups were compared, and the occurrence of adverse reactions during the treatment period was statistically analyzed. Results: After 3 months of treatment, the total effective rate of the study group was higher than that of the control group (75.00% vs 42.50%; p < 0.05). After 1, 2, and 3 months of treatment, the visual analogue scale (VAS) scores of pain in both groups were decreased, and the degree of decrease in the study group was greater than that in the control group (p < 0.05). After 3 months of treatment, the temperatures of the Shenque, and lower abdomen in the study group were lower than those in the control group (p < 0.05). During the treatment period, no adverse reactions such as nausea, vomiting, or dizziness occurred in either group. Conclusion: The self-designed Nuangong Zhitong Ling has significant application value in PD of cold coagulation syndrome, which can provide clinical efficacy via relieving pain symptoms and improving local tissue temperature changes to remove cold retention and blockage, without serious adverse reactions yet with good safety.