The Association of D-Dimer with COVID-19

Background: In order to monitor, prognosis, and formulate treatment algorithms for COVID-19, it is essential to identify severe infection parameters.Objectives: Using D-dimer levels to measure COVID-19 severity, this study aims to investigate the relationship between D-dimer levels and severity.Methods: The study was conducted in alignment with the established guidelines for meta-analyses and systematic reviews. The systematic search utilized ScienceDirect and MEDLINE/PubMed databases. A random effects model was used to estimate the pooled estimates.Results: The meta-analysis has a weighted mean difference of 0.87 g/mL between mild and severe D-dimer (95% CI 0.74, 0.93). There was a significant presence of publication bias. Meta-regression analysis revealed that 58 out of 103 clinical factors correlated with levels of D-dimer. Additionally, age and gender served as confounding variables. Twenty-two variables were discovered to be independently associated with levels of D-dimer, including glucose, respiratory rate, systolic blood pressure, AST, ALT, and bilirubin.Conclusion: In severe cases of COVID-19, elevated D-Dimer levels are associated with the disease. COVID-19 patients may exhibit these laboratory markers, indicating deteriorating health and unfavorable outcomes.