Effect of Acoramidis on Recurrent and Cumulative Cardiovascular Outcomes in ATTR-CM
Acoramidis significantly reduced the cumulative burden of CV outcomes in ATTR-CM over 30 months. Numerically fewer events were observed with acoramidis vs placebo by month 1, and the difference increased progressively over time, resulting in 53 events avoided per 100 treated patients at month 30. Almost one-fourth of the cumulative CV events occurred within the first 6 months. These exploratory findings suggest that cumulative event burden may occur early, highlighting the importance of timely evaluation, diagnosis and treatment in ATTR-CM.
Authors
- Adam Castaño (ORCID: https://orcid.org/0000-0003-4482-5840)
- Frederick L. Ruberg (ORCID: https://orcid.org/0000-0002-6424-4413)
- Ronald Witteles (ORCID: https://orcid.org/0000-0002-3043-1472)
- Suresh Siddhanti
- Richard Kar-Hang Cheng (ORCID: https://orcid.org/0000-0001-5994-5998)
- Steen Hvitfeldt Poulsen (ORCID: https://orcid.org/0000-0002-9586-835X)
- Justin L. Grodin (ORCID: https://orcid.org/0000-0003-2400-3196)
- Sarah Cuddy (ORCID: https://orcid.org/0000-0002-2124-2151)
- Kuangnan Xiong (ORCID: https://orcid.org/0009-0006-4898-539X)
- Gillian Murtagh (ORCID: https://orcid.org/0000-0001-5963-5244)
- Julian D. Gillmore (ORCID: https://orcid.org/0000-0001-6174-9232)
- Amrut V. Ambardekar (ORCID: https://orcid.org/0000-0003-3503-4203)
- Matthew J. Maurer (ORCID: https://orcid.org/0000-0002-1867-0526)
- Ahmad Masri (ORCID: https://orcid.org/0000-0002-6390-6526)
- Laura Piera Obici (ORCID: https://orcid.org/0000-0001-7468-700X)
- Daniel Philip Judge (ORCID: https://orcid.org/0000-0002-3407-0248)
- Kevin Michael Alexander (ORCID: https://orcid.org/0000-0003-4024-3691)
- Peter van der Meer (ORCID: https://orcid.org/0000-0002-9705-4413)
- Jean‐François Tamby (ORCID: https://orcid.org/0009-0002-8892-4488)
- Xiaofan Cao
- Jonathan C. Fox (ORCID: https://orcid.org/0000-0002-1250-5239)
Institutions
- Boston University (US)
- Brigham and Women's Hospital (US)
- Boston Medical Center (US)
- Parkland Health & Hospital System (US)
- University Medical Center Groningen (NL)
- Medical University of South Carolina (US)
- Oregon Health & Science University (US)
- University of Groningen (NL)
- University of Washington (US)
- Columbia University Irving Medical Center (US)
- The Royal Free Hospital (GB)
- Aarhus University Hospital (DK)
- BridgeBio (United States) (US)
- Stanford Medicine (US)
- Bridge Pharma (United States) (US)
- University College London (GB)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
- Stanford University (US)
Publication Details
- Journal
- Journal of the American College of Cardiology
- Published
- 2025-09-28
- DOI
- https://doi.org/10.1016/j.jacc.2025.09.013
- Citations
- 3
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 3.67