Abstract B051: Trends in pancreatic cancer and renal failure-related mortality among adults in the United States from 1999 to 2020

Abstract Background: Pancreatic cancer, the third leading cause of cancer-related deaths in the United States, and renal failure often coexist and pose a huge healthcare burden. We conducted this study to evaluate the trends in pancreatic cancer and renal failure-related mortality among adults in the United States from 1999 to 2020. Methods: Mortality data among adults aged 25 years and older were extracted from the CDC WONDER database, using ICD-10 codes C25 and N17-N19. Age-adjusted mortality rates (AAMR) per 100,000 persons were calculated and stratified by sex, race/ethnicity, Hispanic/non-Hispanic origin, urbanization, and census region. Trends were analyzed using the Joinpoint regression software to calculate annual percent changes (APC) with 95% confidence intervals (CI). Results: We identified 23,024 deaths from 1999 to 2020, with an overall AAMR of 0.49. From 2014 to 2020, the AAMR increased significantly (APC: 2.37; 95% CI, 0.80 to 3.96; p = 0.005827). Although men had a higher AAMR than women (0.62 versus 0.34), women had a higher rate of rise (APC: 5.13; 95% CI, 1.26 to 9.15; p = 0.012596) than men (APC: 3.91; 95% CI, 0.97 to 6.93; p = 0.012487) from 2015 to 2020. Analysis by race showed the highest AAMR among the Non-Hispanic (NH) Blacks or African Americans (0.95), followed by Hispanics (0.44), NH Whites (0.42), NH American Indians or Alaska Natives (0.41), and the NH Asians or Pacific Islanders (0.40). While NH Whites (1999-2020) showed a consistent uptrend (APC: 1.65; 95% CI, 0.91 to 2.39; p = 0.000149), NH Asians (2001-2020) had a declining trend (APC: -2.00; 95% CI, -3.22 to -0.78; p = 0.003084). Regionally, the Midwest and South showed uptrends throughout the study period with APCs of 1.15 (95% CI, 0.32 to 1.99; p = 0.008808) and 1.61 (95% CI, 0.96 to 2.26; p = 0.000042), respectively. While West (1999-2011) had the highest rate of increase (APC: 3.80; 95% CI, 1.16 to 6.50; p = 0.007128), Northeast (2011-2020) had the highest rate of decrease (APC: -2.09; 95% CI, -3.98 to -0.16; p = 0.035440). Regarding urbanization, Small Metropolitan areas (2015-2020) experienced the highest rate of rise (APC: 9.76; 95% CI, 2.97 to 16.99; p =0.007396). Conclusions: Pancreatic cancer and renal failure-related mortality rates have increased significantly since 2014, with variations among different demographic and geographic subgroups. This highlights the need for targeted interventions to address the comorbid conditions, particularly among the high-burden groups. Citation Format: Sravani Bhavanam, Hakim Wazir, abdul Majid, Nayanika Tummala, Yukti Mudiam, Arisha Akthar, Sania Batool, Aman Iqbal, Muhammad Umar, Amna Amjad, Yassar ul. Mulk. Trends in pancreatic cancer and renal failure-related mortality among adults in the United States from 1999 to 2020 [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Advances in Pancreatic Cancer Research—Emerging Science Driving Transformative Solutions; Boston, MA; 2025 Sep 28-Oct 1; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2025;85(18_Suppl_3):Abstract nr B051.