Are Inflammatory Markers Useful in Determining The Anatomic Localisation of Colorectal Cancer? Immature Granulocytes and Red Cell Distributon Width.

Background: There are embryological, clinicopathlogical, and prognostic differences between right and left colon tumours. The aim of this study was to investigate the diagnostic benefit of inflammatory markers in the differentiation of right and left colon cancers. Methods: Two groups of patients were formed as 71 (33.8%) with right colon cancer (RCC) and 139 (66.2%) with left colorectal cancer (LCRC). The groups were compared in respect of clinical characteristics, hemoglobin, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic immune inflammation index (SII), immature granulocyte count (IGC), immature granulocyte percentage (IG%), and red blood cell distribution width percentage (RDW%). Results: The TNM grade, and NLR, PLR, SII, IGC, and IG% values were similar in both groups. In the RCC group, hemoglobin was determined to be lower than in the LCRC group (11.35 [6.40-16.40] vs. 13.00 [6.00-17.00] mg/dl), and RDW was higher (14.80% [11.90-27.90] vs. 13.70% [11.00-37.10]) (p=0.001, p=0.005, respectively). In ROC analysis, hemoglobin (AUC:0.640, p