Hypertonic Saline or Carbocisteine in Bronchiectasis
In participants with bronchiectasis, neither hypertonic saline nor carbocisteine significantly reduced the mean incidence of pulmonary exacerbations over a period of 52 weeks. (Funded by the National Institute for Health and Care Research Health Technology Assessment Programme and others; ISRCTN Registry number, ISRCTN89040295.).
Authors
- Adam T. Hill (ORCID: https://orcid.org/0000-0002-1789-9257)
- Clíona McDowell (ORCID: https://orcid.org/0000-0002-7644-7197)
- John Steer (ORCID: https://orcid.org/0000-0003-4415-8814)
- S. Caskey
- Kathryn M. Ferguson (ORCID: https://orcid.org/0000-0002-7671-5403)
- Timothy Gatheral (ORCID: https://orcid.org/0000-0003-2677-8729)
- Denise Cosgrove
- Judy Martina Bradley (ORCID: https://orcid.org/0000-0002-7423-135X)
- Milan Bhattacharya
- Michael R. Loebinger (ORCID: https://orcid.org/0000-0002-5965-9913)
- John Robert Hurst (ORCID: https://orcid.org/0000-0002-7246-6040)
- J.S. Elborn (ORCID: https://orcid.org/0000-0002-2323-442X)
- Daniel Francis McAuley (ORCID: https://orcid.org/0000-0002-3283-1947)
- Rebecca H. McLeese (ORCID: https://orcid.org/0000-0003-0647-2503)
- Terence McManus
- Christina Campbell (ORCID: https://orcid.org/0000-0002-8446-523X)
- Rory Convery
- Nick P. Talbot (ORCID: https://orcid.org/0000-0002-9186-8950)
- D.G. Downey (ORCID: https://orcid.org/0000-0002-6471-549X)
- A. Sullivan (ORCID: https://orcid.org/0000-0001-8313-1484)
- James Duncan Chalmers (ORCID: https://orcid.org/0000-0001-5514-7868)
- Mary Carroll (ORCID: https://orcid.org/0000-0001-5396-221X)
- W.G. Flight (ORCID: https://orcid.org/0000-0003-3343-4211)
- John Norrie (ORCID: https://orcid.org/0000-0001-9823-9252)
- Amelia Shoemark (ORCID: https://orcid.org/0000-0001-7360-6060)
- Mike J Clarke (ORCID: https://orcid.org/0000-0002-2926-7257)
- Anthony De Soyza (ORCID: https://orcid.org/0000-0002-8566-0344)
- A Ionescu (ORCID: https://orcid.org/0000-0002-3984-9373)
- J. Duckers (ORCID: https://orcid.org/0000-0003-3004-279X)
- Chris Hagan
- Vijayendra Patil
- Brenda O’Neill (ORCID: https://orcid.org/0000-0002-6471-1413)
- Fiona Copeland
- Gareth Davies (ORCID: https://orcid.org/0000-0002-6457-6952)
- Ashley Agus (ORCID: https://orcid.org/0000-0001-9839-6282)
- Muhammad Anwar (ORCID: https://orcid.org/0000-0003-2561-583X)
- Andrew Jackson (ORCID: https://orcid.org/0000-0002-4781-9633)
- Martin Kelly (ORCID: https://orcid.org/0000-0003-1462-815X)
- Mitra Shahidi (ORCID: https://orcid.org/0009-0007-4132-2873)
- Mohamed Etumi
Institutions
- Queen's University Belfast (GB)
- Belfast Health and Social Care Trust (GB)
- Cardiff and Vale University Health Board (GB)
- University of Ulster (GB)
- University Hospitals of Morecambe Bay NHS Foundation Trust (GB)
- University of Dundee (GB)
- Royal Gwent Hospital (GB)
- Northumbria Healthcare NHS Foundation Trust (GB)
- Buckinghamshire Healthcare NHS Trust (GB)
- University Hospitals of Leicester NHS Trust (GB)
- Ninewells Hospital (GB)
- Edinburgh Royal Infirmary (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- Western Health and Social Care Trust (GB)
- Royal Brompton Hospital (GB)
- Lung Institute (US)
- Southern Health and Social Care Trust (GB)
- Blackpool Teaching Hospitals NHS Foundation Trust (GB)
- Sağlık Bilimleri Üniversitesi (TR)
- NIHR Surgical Reconstruction and Microbiology Research Centre (GB)
- Milton Keynes Hospital NHS Foundation Trust (GB)
- Princess Alexandra Hospital (GB)
- Oxford University Hospitals NHS Trust (GB)
- Centre for Inflammation Research (GB)
- University College London (GB)
- Imperial College London (GB)
- Newcastle University (GB)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-09-28
- DOI
- https://doi.org/10.1056/nejmoa2510095
- Citations
- 12
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 18.22
Funders
- Johns Hopkins University
- University Hospital Southampton NHS Foundation Trust
- Royal Free London NHS Foundation Trust
- University of Oxford
- Oxford University Hospitals NHS Foundation Trust