Hypertonic Saline or Carbocisteine in Bronchiectasis

In participants with bronchiectasis, neither hypertonic saline nor carbocisteine significantly reduced the mean incidence of pulmonary exacerbations over a period of 52 weeks. (Funded by the National Institute for Health and Care Research Health Technology Assessment Programme and others; ISRCTN Registry number, ISRCTN89040295.).

Authors

Institutions

Publication Details

Journal
New England Journal of Medicine
Published
2025-09-28
DOI
https://doi.org/10.1056/nejmoa2510095
Citations
12
Primary Topic
Neonatal Respiratory Health Research
Type
article
Field-Weighted Citation Impact
18.22

Funders

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article

Hypertonic Saline or Carbocisteine in Bronchiectasis

Adam T. Hill, Clíona McDowell, John Steer, S. Caskey et al.
12 citations
New England Journal of Medicine
Neonatal Respiratory Health Research
18.22
article

Hypertonic Saline or Carbocisteine in Bronchiectasis

Adam T. Hill, Clíona McDowell, John Steer, S. Caskey, Kathryn M. Ferguson, Timothy Gatheral, Denise Cosgrove, Judy Martina Bradley, Milan Bhattacharya, Michael R. Loebinger, John Robert Hurst, J.S. Elborn, Daniel Francis McAuley, Rebecca H. McLeese, Terence McManus, Christina Campbell, Rory Convery, Nick P. Talbot, D.G. Downey, A. Sullivan, James Duncan Chalmers, Mary Carroll, W.G. Flight, John Norrie, Amelia Shoemark, Mike J Clarke, Anthony De Soyza, A Ionescu, J. Duckers, Chris Hagan, Vijayendra Patil, Brenda O’Neill, Fiona Copeland, Gareth Davies, Ashley Agus, Muhammad Anwar, Andrew Jackson, Martin Kelly, Mitra Shahidi, Mohamed Etumi
article en
12 citations

Abstract

In participants with bronchiectasis, neither hypertonic saline nor carbocisteine significantly reduced the mean incidence of pulmonary exacerbations over a period of 52 weeks. (Funded by the National Institute for Health and Care Research Health Technology Assessment Programme and others; ISRCTN Registry number, ISRCTN89040295.).

New England Journal of MedicineVol. 393(16)
Queen's University Belfast (GB), Belfast Health and Social Care Trust (GB), Cardiff and Vale University Health Board (GB), University of Ulster (GB), University Hospitals of Morecambe Bay NHS Foundation Trust (GB), University of Dundee (GB), Royal Gwent Hospital (GB), Northumbria Healthcare NHS Foundation Trust (GB), Buckinghamshire Healthcare NHS Trust (GB), University Hospitals of Leicester NHS Trust (GB), Ninewells Hospital (GB), Edinburgh Royal Infirmary (GB), University Hospital Southampton NHS Foundation Trust (GB), Western Health and Social Care Trust (GB), Royal Brompton Hospital (GB), Lung Institute (US), Southern Health and Social Care Trust (GB), Blackpool Teaching Hospitals NHS Foundation Trust (GB), Sağlık Bilimleri Üniversitesi (TR), NIHR Surgical Reconstruction and Microbiology Research Centre (GB), Milton Keynes Hospital NHS Foundation Trust (GB), Princess Alexandra Hospital (GB), Oxford University Hospitals NHS Trust (GB), Centre for Inflammation Research (GB), University College London (GB), Imperial College London (GB), Newcastle University (GB)
Johns Hopkins University, University Hospital Southampton NHS Foundation Trust, Royal Free London NHS Foundation Trust, University of Oxford, Oxford University Hospitals NHS Foundation Trust
Openalex Percentile: Top 1%
Neonatal Respiratory Health Research
18.22
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