Generation of orthotopic intracranial glioblastoma patient-derived xenograft models: insights into extrachromosomal DNA-driven MYC(N) and PDGFRA oncogene amplification and preliminary therapeutic evaluation
Intracranial PDX models were successfully established from cryopreserved GBM tissues through subcutaneous expansion. These models offer a clinically relevant platform for investigating GBM biology and evaluating the therapeutic efficacy of chemoimmunotherapy.
Authors
- Ahyeon Shim
- Thi-Anh-Thuy Tran (ORCID: https://orcid.org/0000-0002-3273-0919)
- Shin Jung (ORCID: https://orcid.org/0000-0003-2587-1243)
- Sue Jee Park
- Chul Won Lee (ORCID: https://orcid.org/0000-0002-3205-675X)
- Yeong Jin Kim (ORCID: https://orcid.org/0000-0003-0376-6784)
- Sinae An
- Junghyun Lim (ORCID: https://orcid.org/0000-0002-5292-7487)
- Kyunghwa Lee (ORCID: https://orcid.org/0000-0002-2515-6891)
- Hawsan Kim
- Kyung‐Sub Moon (ORCID: https://orcid.org/0000-0002-1129-1064)
- In‐Young Kim (ORCID: https://orcid.org/0000-0002-1152-119X)
- Ae Kyung Park
- Tiantian Han (ORCID: https://orcid.org/0000-0002-4635-7174)
- Tae-Young Jung
- Young-Hee Kim
Institutions
- Chonnam National University (KR)
- Jeonbuk State Institute (KR)
- Chonnam National University Hwasun Hospital (KR)
- Jeonbuk National University (KR)
Publication Details
- Journal
- Neoplasia
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1016/j.neo.2025.101233
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00