Association of interleukin-6 serum levels with local tumor stage and lymph node metastasis of urothelial carcinoma
This prospective study found that elevated preoperative IL-6 serum levels correlated with local tumor stage and were associated with lymph node metastasis in UC patients undergoing RC. However, IL-6 levels were also elevated in patients with other oncologic or nononcologic indications for RC, underscoring the need for careful interpretation of this marker.
Authors
- Gerald Bastian Schulz (ORCID: https://orcid.org/0000-0002-0340-0304)
- Lennert Eismann (ORCID: https://orcid.org/0000-0002-9971-4411)
- Michael Chaloupka (ORCID: https://orcid.org/0000-0002-8814-6412)
- Yannic Volz (ORCID: https://orcid.org/0000-0002-5468-9398)
- Maria Apfelbeck (ORCID: https://orcid.org/0000-0002-9223-9291)
- Sarah Takayama Fouladgar
- Nikolaos Pyrgidis (ORCID: https://orcid.org/0000-0002-7707-8426)
- Benedikt Ebner (ORCID: https://orcid.org/0000-0003-2126-7305)
- Julian Hermans
- A. Ewert
- Philipp Weinhold (ORCID: https://orcid.org/0000-0002-9144-9289)
- Philipp M. Kazmierczak (ORCID: https://orcid.org/0000-0003-0071-1665)
- Christian Georg Stief (ORCID: https://orcid.org/0000-0003-3291-9460)
- Julian Marcon (ORCID: https://orcid.org/0000-0001-5304-817X)
- Marc Anwar Kidess (ORCID: https://orcid.org/0009-0005-2072-5521)
- Annkathrin Holz
- Judith Hirsch
- Marie Semmler (ORCID: https://orcid.org/0009-0003-5634-3627)
- Iason Papadopoulos
Institutions
- LMU Klinikum (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Urologic Oncology Seminars and Original Investigations
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.urolonc.2025.08.026
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09