Critical role of transcription factor SOX4 in tubular epithelial cell dedifferentiation and fibroblast activation during kidney fibrosis
Our findings identify SOX4 as a critical factor in TEC dedifferentiation and fibroblast activation suggesting SOX4 may serve as a potential therapeutic target for the treatment of CKD.
Authors
- Xing Jian (ORCID: https://orcid.org/0000-0002-0043-8729)
- Baihai Jiao (ORCID: https://orcid.org/0000-0002-2217-981X)
- Melanie Tran (ORCID: https://orcid.org/0000-0003-1427-841X)
- Yanlin Wang (ORCID: https://orcid.org/0000-0002-6908-1529)
- Penghua Wang
- Véronique Lefebvre (ORCID: https://orcid.org/0000-0003-2225-8267)
- Zhaoyong Hu
- Dong Zhou
- Hao Du
- Dong Yang
Institutions
- Children's Hospital of Philadelphia (US)
- University of Connecticut (US)
- Baylor College of Medicine (US)
- Yale University (US)
- UConn Health (US)
Publication Details
- Journal
- Kidney International
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1016/j.kint.2025.08.030
- Citations
- 4
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 3.22