Aqueous Electrophilic Aromatic Bromination using KBr and Oxone

Electrophilic aromatic bromination reactions are an important class of chemical transformations used to synthesize key intermediates and products. We report an experimental procedure for the bromination of 4-methylanisole using KBr and Oxone in water that can be completed in 40 min at room temperature. This procedure incorporates several principles of green chemistry, providing a safer alternative to the traditional method used for bromination of aromatic compounds. The crude reaction product was characterized using IR and 1H NMR.