Determining the Efficacy of Octreotide on Lymphorrhea Formation in Patients With Early Breast Carcinoma After Modified Radical Mastectomy: A Randomized Controlled Trial

Adjuvant octreotide significantly reduced the volume of lymphorrhea following MRM, with quicker drain removal indicating its potential to decrease drainage output. Although the octreotide group showed a trend towards lower seroma incidence, the relationship was not statistically significant in our sample. Octreotide was well tolerated with no significant side effects. These findings suggest octreotide can be a safe adjunct to standard surgical care to reduce lymphatic drainage after MRM. Larger studies may further clarify its impact on seroma formation and recovery.