Exosomes derived from ADSC suppress endothelial cells ferroptosis and alleviate sepsis acute liver injury via regulation of Keap1/Nrf2/GPX4 axis
These findings demonstrate the remarkable ability of ADSC-exo to alleviate sepsis-induced ALI by mitigating endothelial cell ferroptosis, providing evidence for the potential clinical application of ADSC-exo in ALI therapy.
Authors
- Yanan Xu (ORCID: https://orcid.org/0000-0002-8843-9426)
- Xian-Jie Xu
- Dan Wu (ORCID: https://orcid.org/0000-0002-6661-2961)
- Shanshou Liu (ORCID: https://orcid.org/0000-0001-5036-955X)
- Qianmei Wang
- Xianqi Wang
- Haian Fu (ORCID: https://orcid.org/0000-0002-2362-7979)
- Junjie Li (ORCID: https://orcid.org/0000-0003-2152-6952)
- Xiaoyang Liu (ORCID: https://orcid.org/0000-0002-1202-6764)
- Zheng Dai
- Qi Zhang (ORCID: https://orcid.org/0000-0002-6096-0690)
- Yuexiang Ma
- Wen Yin
- Kuo Shen
- Peiwen Wang (ORCID: https://orcid.org/0009-0008-6225-4299)
Institutions
- Command Hospital Air Force (IN)
- Xijing Hospital (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Stem Cells
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1093/stmcls/sxaf063
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81