Lifestyle Cost-Effective Strategies for Tamsulosin HCl Extended-Release Tablets Using Polymer Mixtures for Solubility Improvement

The present research was designed to investigate the extraction, purification, and characterization of cashew gum, as well as its combination with HPMC and xanthan gum, in pharmaceutical applications. In this research, we prepared ten formulations by varying the quantity of cashew gum. The cashew gum recovery rate from the purifying procedure was 72.26%. The viscosity, swelling index, particle size distribution, and bulk density of cashew gum were determined, along with several physical, rheological, and flow characteristics that were examined. The use of these gums, along with HPMC and xanthan gum, in the production of Tamsulosin HCl matrix tablets was also investigated in this study. To assess the tablets' performance, quality control tests were carried out, including weight uniformity, friability, crushing strength, swelling index, and dissolution investigations. According to regulatory requirements, some formulations produced sustained drug release over 24 hours, as shown by the release kinetics and drug dissolution profiles. To evaluate the reliability and compatibility of the excipients, characterization methods including X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and Fourier transform infrared spectroscopy (FTIR) were used. FTIR spectra show different peaks of functional groups. Scanning Electron Microscopy analysis shows that the tablet surface was porous. The results show that cashew gum is a good substitute for a pharmaceutical excipient that might be used in formulations for controlled drug release