Exploring the Link Between Hepatitis A and B Vaccination and Social Support in the US Population: Insights from the NHANES 2005-2006 Cohort

Background: High social support is easily assessed and associated with a healthier lifestyle, including vaccination adherence. Similarly, immunization is a widely available public health statistic associated with healthier behaviors. However, the link between the hepatitis immunization status and social support needs to be explored. Methods: We assessed the association between levels of social support and hepatitis immunization status using the National Health and Nutrition Examination Survey (NHANES), a cross-sectional multidisciplinary database publicly available for researchers. With 2005–2006 data, 2997 participants were included. Statistical analyses were conducted using STATA18.5v software, including the odds ratio of both univariable logistic regression and multivariable logistic regression. After adjusting for clinically relevant confounders, two distinct models were designed: 1) full immunization, and 2) incomplete immunization. Results: Multivariable analysis revealed significantly greater odds of high social support for participants fully or partially immunized against both hepatitis A and B: 3.15 (95% CI 1.03–9.66,p=0.04) and 3.35 (95% CI 1.15–9.75,p=0.03), respectively. Conclusion: Our findings show an association between vaccination and social support in both adjusted models. Individuals not vaccinated at all may behave differently from those willing to be, at least partially, immunized. It seems that a similar behavior that may lead to vaccination may also lead to increased social support. Therefore, our study suggests that hepatitis vaccination could perhaps be a surrogate marker for public-health-related outcomes.

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Journal
Principles and Practice of Clinical Research Journal
Published
2025-09-26
DOI
https://doi.org/10.21801/ppcrj.2025.112.6
Primary Topic
Hepatitis Viruses Studies and Epidemiology
Type
article
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article

Exploring the Link Between Hepatitis A and B Vaccination and Social Support in the US Population: Insights from the NHANES 2005-2006 Cohort

Fernando Romariz Duarte, Patricia Rioja, Antonio J. Ramírez, Maria Magalhaes et al.
Principles and Practice of Clinical Research Journal
Hepatitis Viruses Studies and Epidemiology
article

Exploring the Link Between Hepatitis A and B Vaccination and Social Support in the US Population: Insights from the NHANES 2005-2006 Cohort

Fernando Romariz Duarte, Patricia Rioja, Antonio J. Ramírez, Maria Magalhaes, Maria Antonieta Lopes, Jorge Alave, Ashley Chin, Y. Wendy Huynh, Isabel Cabral, Beatrice Dal Bianco, Rebecca Santos Soares, Rintu Sharma, Hoàng Bách Nguyễn, Jessica Rodriguez, A.P. Carvalho, L. Viola, Walter Enrique Mogrovejo Ramos, Daniel Bancovsky, Omar E. Vásquez-Pérez, Asma Qudayr, Cynthia L. P. de Borborema, Fabricio Kleber, Faiez Alsatou, Ilgin Genc, Manjushree Shastry, Juliana Calit, Lucas Vidoto, Ricardo E. Nunez-Rocha, Martina Caccamo, Barbara Grohmann, Merce Avellanet, Magali Coyoy-Say, Sebastine Oiwoh, Kumud Chapagain, Ignacio Montealegre
article en

Abstract

Background: High social support is easily assessed and associated with a healthier lifestyle, including vaccination adherence. Similarly, immunization is a widely available public health statistic associated with healthier behaviors. However, the link between the hepatitis immunization status and social support needs to be explored. Methods: We assessed the association between levels of social support and hepatitis immunization status using the National Health and Nutrition Examination Survey (NHANES), a cross-sectional multidisciplinary database publicly available for researchers. With 2005–2006 data, 2997 participants were included. Statistical analyses were conducted using STATA18.5v software, including the odds ratio of both univariable logistic regression and multivariable logistic regression. After adjusting for clinically relevant confounders, two distinct models were designed: 1) full immunization, and 2) incomplete immunization. Results: Multivariable analysis revealed significantly greater odds of high social support for participants fully or partially immunized against both hepatitis A and B: 3.15 (95% CI 1.03–9.66,p=0.04) and 3.35 (95% CI 1.15–9.75,p=0.03), respectively. Conclusion: Our findings show an association between vaccination and social support in both adjusted models. Individuals not vaccinated at all may behave differently from those willing to be, at least partially, immunized. It seems that a similar behavior that may lead to vaccination may also lead to increased social support. Therefore, our study suggests that hepatitis vaccination could perhaps be a surrogate marker for public-health-related outcomes.

Principles and Practice of Clinical Research JournalVol. 11
Peace Corps (US), Beth Israel Deaconess Medical Center (US), Harvard University (US), Universidad de San Carlos de Guatemala (GT), Pontificia Universidad Católica Madre y Maestra (DO), Taif University (SA), Kazan State Medical University (RU), University of Cuenca (EC), McLean Hospital (US), Princess Margaret Cancer Centre (CA), Universidade de Caxias do Sul (BR), Real Hospital Português (BR), Central America Health Sciences University (BZ), Hydal Aluminium Profiler (Norway) (NO), IQVIA (India) (IN), Hospital Alemão Oswaldo Cruz (BR), Ospedale A. Perrino (IT), Syneos Health (United States) (US), Centro Clinico Nemo (IT), Incell Corporation (United States) (US), Sarah Network of Rehabilitation Hospitals (BR), Instituto Nacional de Enfermedades Neoplásicas (PE), Faculdade São Leopoldo Mandic (BR), Southwest Scoliosis Institute (US), Universidad Peruana Unión (PE), Hospital Universitário da Universidade de São Paulo (BR), Edmond and Lily Safra Children's Hospital (IL), Fleury S.A. (Brazil) (BR), Westsächsische Hochschule Zwickau (DE), Irrua Specialist Teaching Hospital (NG), Klinikum Chemnitz (DE), B.P. Koirala Institute of Health Sciences (NP), The University of Texas Southwestern Medical Center (US), Universidade Federal de São Paulo (BR)
Openalex Percentile: Top 64%
Hepatitis Viruses Studies and Epidemiology
DOIOpen Access PDFOpenAlex
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