Effectiveness and safety of tenofovir alafenamide fumarate–based therapy compared with tenofovir disoproxil fumarate- and abacavir-based therapy in children and young people living with HIV in Europe
Virological outcomes were similar across drugs. Rates of any grade laboratory events were highest on TAF, driven by higher rates of lipid events. As TAF uptake increases, studies with long-term follow-up are required.
Authors
- Hannah Castro (ORCID: https://orcid.org/0000-0001-9086-8687)
- Alasdair Bamford (ORCID: https://orcid.org/0000-0003-4764-229X)
- Magdalena Marczyńska (ORCID: https://orcid.org/0000-0001-5731-6346)
- Caroline Foster (ORCID: https://orcid.org/0000-0002-3544-3261)
- P Paioni (ORCID: https://orcid.org/0000-0002-3904-1606)
- Siobhan Crichton (ORCID: https://orcid.org/0000-0001-9962-083X)
- Lars Navér (ORCID: https://orcid.org/0000-0001-6027-0211)
- Andrea Marongiu (ORCID: https://orcid.org/0000-0001-7038-3615)
- Christoph Königs (ORCID: https://orcid.org/0000-0003-4597-2439)
- Elizabeth Chappell (ORCID: https://orcid.org/0000-0003-1053-6434)
- Jorge Gómez Sirvent
- Ali Judd (ORCID: https://orcid.org/0000-0003-3176-5295)
- Intira Jeannie Collins (ORCID: https://orcid.org/0000-0003-2132-6037)
- Charlotte Jackson (ORCID: https://orcid.org/0000-0001-8544-7685)
- Vinícius Vieira (ORCID: https://orcid.org/0000-0002-4901-0424)
- Vana Spoulou (ORCID: https://orcid.org/0000-0001-5467-0630)
- Antoni Noguera‐Julián (ORCID: https://orcid.org/0000-0001-7485-0583)
- Luminiţa Ene (ORCID: https://orcid.org/0000-0002-1608-8575)
- John O’Rourke
- Katja Doerholt (ORCID: https://orcid.org/0000-0001-5105-0970)
- Elena Chiappini (ORCID: https://orcid.org/0000-0002-1476-4752)
- Marisa Navarro (ORCID: https://orcid.org/0000-0002-1234-6936)
- Sandra Soeria‐Atmadja (ORCID: https://orcid.org/0000-0003-0552-6872)
- Beatriz Álvarez Vallejo
- Tessa Goetghebuer
- Sannie Brit Nordly
Institutions
- MRC Clinical Trials Unit at UCL (GB)
- University College London (GB)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.ijantimicag.2025.107634
- Citations
- 1
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.40