Molecular profile of interleukin-17RA blockade by brodalumab in Japanese patients with psoriasis: Results from the ESPRIT study
In summary, the transcriptome and the proteome characteristics of Japanese and Western psoriasis patients were similar. Brodalumab rapidly improved skin and serum molecular levels and reduced cardiovascular disease risk factor expression.
Authors
- Naomi Shishido (ORCID: https://orcid.org/0000-0002-0429-9033)
- Chiharu Tateishi (ORCID: https://orcid.org/0000-0002-3597-0926)
- Hong Hur (ORCID: https://orcid.org/0000-0002-4088-9188)
- Eisaku Ogawa (ORCID: https://orcid.org/0000-0002-9293-7022)
- James G. Krueger (ORCID: https://orcid.org/0000-0002-3775-1778)
- Yukie Yamaguchi (ORCID: https://orcid.org/0000-0002-0297-6627)
- Sandra Garcet
- Akimichi Morita (ORCID: https://orcid.org/0000-0001-8372-3754)
- Koji Masuda (ORCID: https://orcid.org/0000-0003-2338-8450)
- Yasumasa Kanai (ORCID: https://orcid.org/0009-0005-0300-4917)
- Mona Uchida‐Yamada (ORCID: https://orcid.org/0000-0002-5781-9485)
Institutions
- Shinshu University (JP)
- Kyowa Kirin (Japan) (JP)
- Nagoya City University (JP)
- Kyoto Prefectural University of Medicine (JP)
- Osaka Metropolitan University (JP)
- Tokyo Metropolitan University (JP)
- Rockefeller University (US)
- Yokohama City University (JP)
Publication Details
- Journal
- Journal of Dermatological Science
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.jdermsci.2025.09.005
- Citations
- 1
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.80