Real-World Effectiveness of Second-Line Therapies in Advanced Non-Small Cell Lung Cancer: Insights From Propensity-Weighted Comparative Analyses of Longitudinal EHR Data

Longitudinal real-world data can enhance assessment of 2L therapy effectiveness. After confounder adjustment, we found clinically meaningful survival differences by 2L choice. These findings underscore the importance of 2L treatment selection and the need for prospective validation.

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Publication Details

Journal
Clinical Lung Cancer
Published
2025-09-27
DOI
https://doi.org/10.1016/j.cllc.2025.09.010
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
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article

Real-World Effectiveness of Second-Line Therapies in Advanced Non-Small Cell Lung Cancer: Insights From Propensity-Weighted Comparative Analyses of Longitudinal EHR Data

Gary Hettinger, Ravi B. Parikh, Qi Long
Clinical Lung Cancer
Lung Cancer Treatments and Mutations
article

Real-World Effectiveness of Second-Line Therapies in Advanced Non-Small Cell Lung Cancer: Insights From Propensity-Weighted Comparative Analyses of Longitudinal EHR Data

Gary Hettinger, Ravi B. Parikh, Qi Long
article en

Abstract

Longitudinal real-world data can enhance assessment of 2L therapy effectiveness. After confounder adjustment, we found clinically meaningful survival differences by 2L choice. These findings underscore the importance of 2L treatment selection and the need for prospective validation.

Clinical Lung CancerVol. 27(2)
Emory University (US), New York University (US), University of Pennsylvania (US)
Openalex Percentile: Top 62%
Lung Cancer Treatments and Mutations
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