Metabolomic determinants of sarcopenia incidence: A 14-year prospective study of 33,797 participants

This study identified 38 plasma metabolites associated with incident sarcopenia. Incorporating these metabolites into models with conventional risk factors yielded statistically significant improvements in prediction beyond that of conventional factors alone; however, the gain was modest, and its clinical relevance remains to be determined. These findings suggest that although the clinical utility of these metabolites for predicting sarcopenia incidence has not yet been fully established, they may nevertheless provide insights into underlying biological pathways and could contribute to the development of preventive or therapeutic strategies in geriatric care.