The effects of intracranial stimulation on local neurovascular responses in humans
CBW recordings reveal that high-frequency DBS evokes region-specific vascular responses which can be modeled as substantial increases in local blood flow, establishing CBW amplitude as a potential biomarker of subcortical hemodynamics, and a potential therapeutic modality.
Authors
- William D. Hutchison (ORCID: https://orcid.org/0000-0002-3866-4940)
- Steven Wai Ho Chau (ORCID: https://orcid.org/0000-0002-2986-8677)
- Luka Milosevic (ORCID: https://orcid.org/0000-0002-4051-5397)
- Alexandre Boutet (ORCID: https://orcid.org/0000-0001-6942-5195)
- Suneil K. Kalia (ORCID: https://orcid.org/0000-0003-2054-1915)
- Artur Vetkas (ORCID: https://orcid.org/0000-0002-4487-432X)
- Srdjan Sumarac (ORCID: https://orcid.org/0000-0002-3840-5957)
- Taufik A. Valiante (ORCID: https://orcid.org/0000-0002-3443-3790)
- Andrés M. Lozano (ORCID: https://orcid.org/0000-0001-8257-3694)
- Reese Clinton
- Mojgan Hodaie (ORCID: https://orcid.org/0000-0001-6278-4929)
- Can Sarica (ORCID: https://orcid.org/0000-0001-8419-7426)
- Emily Haniff
- Xilin Liu (ORCID: https://orcid.org/0000-0002-9547-3905)
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Toronto Rehabilitation Institute (CA)
- Ontario Brain Institute (CA)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.brs.2025.09.018
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada