Once-daily dolutegravir/lamivudine fixed-dose formulations in children living with HIV: a pharmacokinetic and safety sub-study nested in the open-label, multicentre, randomised, non-inferiority D3/PENTA 21 trial

The D3/Penta 21 trial is sponsored by Fondazione Penta Onlus ETS (Penta) and funded by ViiV Healthcare.

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Publication Details

Journal
EBioMedicine
Published
2025-09-27
DOI
https://doi.org/10.1016/j.ebiom.2025.105929
Citations
2
Primary Topic
HIV/AIDS drug development and treatment
Type
article
Field-Weighted Citation Impact
2.79

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article

Once-daily dolutegravir/lamivudine fixed-dose formulations in children living with HIV: a pharmacokinetic and safety sub-study nested in the open-label, multicentre, randomised, non-inferiority D3/PENTA 21 trial

Simon Walker, Maria Musisi, Wanna Chamjamrat, B Ruiz et al.
2 citations
EBioMedicine
HIV/AIDS drug development and treatment
2.79
article

Once-daily dolutegravir/lamivudine fixed-dose formulations in children living with HIV: a pharmacokinetic and safety sub-study nested in the open-label, multicentre, randomised, non-inferiority D3/PENTA 21 trial

Simon Walker, Maria Musisi, Wanna Chamjamrat, B Ruiz, Annet Nalugo, Mark Ssenyonga, Suparat Kanjanavanit, Gabija Morkunaite, Yupawan Thaweesombat, Emmanuel Mujyambere, Muzamil Nsibuka Kisekka, Disan Mulima, Magda Conway, Marcel Otim, Adeodata Kekitiinwa, Olivia Gilbert, Max Kiwewa, Caroline Otike, Juliet Ategeka, Alberto Murciano, Jade Sugars, Mercy Tukamushaba, Tumelo Moloantoa, Annet Nanduudu, Joseph Semakula, Tim Roy Cressey, Nicholas Wangwe, Rose Jacqueline Kadhuba, Fabian Okello, A Marchan, Faith Mbasani, Zakkiyya Igbal Jeeva, Bosco Kafufu, Olivia Higiro Kaboggoza, Mariam Naabalamba, Matteo Quartagno, Anna Turkova, Abdul Hamid Kaka, Sisinyana Ruth Mathiba, Emily Lebotsa, Paul Revill, Suwalai Chalermpantmetagul, Ruth Sentongo Nakku, Joseph Mutebo, Jackie Brown, Isabelle Déprez, Namthip Kruenual, Jane Crawley, Pisut Greetanukroh, Zainab Nakivumbi Nassoma, M. Aino, David Marinus Burger, Rodolphe Thiébaut, Dridah Nakiboneka, Sheleika Singh, Paul Ndebele, Anna Parker, Sarah Nakabuye, Stephen J. Ferrando, Angella Baita, Ann M. Buchanan, Raziya Bobat, Stephen Townsend, Helen McIlleron, Barbara Mukanza, Ussanee Srirompotong, Alasdair Bamford, Rashidah Nazzinda, Sakulrat Srirojana, Clàudia Fortuny, Esther Pérez David, Sara L. Fagg, Milly Ndigendawani, Mildred Kabasonga, Avy Violari, Verónica Martín, Sabelo Sam Mhlanga, Diana M. Gibb, Eleni Nastouli, Crispus Katemba, Haseena Cassim, Ezgi Seager, Katie Price, Zaakirah Essack, Thannapat Chankun, Modiehi Helen Mosala, Molly Williams, Sasipass Khannak, David Bodian, Florence Namuli, Theodore Ruel, Winnie Nansamba, Warunee Khamjakkaew, F Balmoi, Moira J. Spyer, Tom Jacobs, Dickson Bbuye, Joanita Nankya Baddokwaya, Carlo Giaquinto, Angela Colbers, Lungile Jafta, Nadia Sabet, Rukchanok Peongjakta, Rebecca Sakwa, Michelle A. Hook, Alexandra Compagnucci, Worathip Sripaoraya, Pablo Rojo, Zaam Zinda Nakawungu, Sukanda Denjanta, Annet Kawuma, Lisanne A. H. Bevers, Sarah Babirye Ssebabi, Mercy Shibemba, Stella Nalusiba, Rebecca Wampamba, Barbara Musoke Nakirya, Lilit Manukyan, Nantika Paiboon, Steven Welch, Brenda Catherine Kakayi, Cristina Epalza, Olayiwola Olalekan Paul, J. B. Koroma, Gerald Businge, Delane Shingadia, Manthana Mitchai, Areerat Kongponoi, Ianire Gallego, Alex Musiime, Richard Isabirye, Nasreen Abrahams, A Omar, Alice Mulindwa, Mandisa Nyati, Grace Miriam Ahimbisibwe, Kanyanee Kaewmamueng, Manuel Gijón, Philippa Musoke, Alessandra Nardone, Francis Katongole, Priscilla Kyobutungi, K Sanchez, Rosemary Namwanje, Naowarat Kunyanone, Sara S. El Zahed, Francis Sserugo, Ritah Mbabazi, David Balamusani, Juliet Nanyonjo, Lindiwe Maseko, Judith Tikabibamu, Maxensia Owor, Z Mtshali, Julian Tusiime, Andrew Owen, Gurusidda Manu, Agnes Mary Mugagga, Jutarat Thewsoongnoen, Nazia Parkar, Hajira Kataike, Luis Prieto, Patamawadee Sudsaard, Hannah Sweeney, Cissy Kityo, Agnes Namuddu, Elizabeth C James, Afaaf Liberty, Nondumiso Xulu, Antoni Noguera‐Julián, Nozibusiso Rejoice Mosia, Saskia N. de Wildt, Chaiwat Ngampiyaskul, Rebecca L. Jensen, G Gavin, Ampika Kaewbundit, Pradthana Ounchanum, Gabriela Toledo, Erinah Kyomukama, L. Grange, Kelly Cripps, Justine Boles, Yvonne Beuvink, Imelda Mahaka, Robert Byuma, Carmen Hidalgo, Warunee Srisuk, Diana Rutebarika, Rujirek Kamolrattana, Joyce Mwebaza, Katja Doerholt, Ebrahim Variava, Moherndran Archary, Margaret J. Thomason, Chayakorn Saewtrakool, Josephine Namusanje, Paula Mubiru Namayanja, Teopista Nakyanzi, Maria Janine Nambusi, C Draleku, I Botha, Sharif Musumba, Emmanuel Mayanja, Laura Thrasyvoulou, Sada Pillay, Pacharaporn Yingyong, Rosie Mngqibisa, Eddie Rubanga, K. Kongsuk, A. Kamkoonmongkol, N. Na Kalasin, P. Phunkhum, Aidah Nakalyango, Suchada Ruenglerdpong, Matt Byott, Gerald Agaba Muzorah, Resty Babirye Okello, Ryan Sabet, Kanokkorn Sawasdichai, Eva Akurut, Muzamil Kisekka, Elizabeth Kaudha, Phyllis Mwesigwa, Ronald Nabimba, Athiporn Rungsapphaiboon, Simangele Bengu, Lu Gao, Balvinder Kaur, Daniel F. Carr, M Moodley, Olivier Denis, Man K. Chan, Mandisa Ngema, Iona White, José Tomás Ramos, Juliet Ankunda, Josephine Kobusingye, Christine Nambi, Christine Namugwanya, Pauline Amuge, Anton Pozniak, Lameck Kiyimba, Victor Musiime, Melanie Rooney, Julius Tumusiime, R P Stokes, C.S.K. Chan, Raungwit Junkaew, Debbie Ford, Elizabeth Obimbo, Bonventure Juma, Deirdre Josipovic, Ezra Lutalo, Lindsay Barker, L Lawrence, Pra-ornsuda Sukrakanchana, Henry Mugerwa, M Mugenyi, Hermione Lyall, Maria Nannungi, Thandanani Madonsela, Anthony Kirabira, T. Arumugam, Henry Balwa, Jameena Elsauko, Mangadalen Nansaigi, Enoch Mulwanyi, Enoch Mulwanyi, Aziida Nabukeera, Immaculate Nayiga Serunjogi, Donald Wagaana, Edith Nabawubye, Harriet Namusisi, Judith Nampewo, Winifred Kaahwa, Doreen Twenatwine, Winifred Luwedde, Ronald Okwera, Derick Balungi, Obed Tumwizere, Ann Kankindi, Ivan Rukundo, Henry Odyek, Barnabas Weere, David Ssebunya, Africano Kamugisha, Emmanual Hakizimana, Charles Nyende, Johnson Tumwesigye, Judith Kainza, Nombuso Nkosi, Shingirai Chimene, Jabu Mkhulise, Innocentia Thandokuhle Mncube, Zethu Mnyandu, Popi Shabalala, Ida Elizabeth Mundhree, Itumeleng Holele, Eva Mogotsi, Angelinah Montwedi, Serame Mokoena, Keabetswe Kotsokoane, Dineo Rampai, Lerato Maretlwa, Palesa Tshipunyane, Iris Matotong, Abraham Mammwn Pattamukkil, Ofhani Harmious Makhari, Zukisa Mpeluza, Nadia Bellingan, Leoni Stytler, Mantwa Kunene, Dipuo Dhlomoza, Thabile Degracia Hlomuka, Valerie Khemese, Doungjai Donngern, Thananya Naksomboon, Wallapa Daechasatain, Wanchalerm Boonsub, Thunyasiri Dechboran, Thanawat Samranphit, Orapin Wannasri, Jiraporn Punyayen, Benjawan Thomyota, Benjama I-nala, Chanthaporn Imbumroong, Rattana Chahmeanprabnakorn, Olamide Alimi, Fanele Bulose, Gugulethu Bomela, Zainab Alkurwi, Alvin Daramola-Rose, Ketwarin Pongkawong, Tiyara Arumugan, Susan Tukamuhebwa, Rachael Namuddu Kikabi, Sarah Nabukalu, Collins Mujyanama, Priscilla Namubiru, Abigail Atwine
article en
2 citations

Abstract

The D3/Penta 21 trial is sponsored by Fondazione Penta Onlus ETS (Penta) and funded by ViiV Healthcare.

EBioMedicineVol. 120
Radboud University Nijmegen (NL), Radboud University Medical Center (NL), PENTA Foundation (IT), ViiV Healthcare (United Kingdom) (GB), Baylor College of Medicine Children’s Foundation (UG), Radboud Institute for Molecular Life Sciences (NL), MUJHU Research Collaboration (UG), GlaxoSmithKline (Canada) (CA), King Edward VIII Hospital (ZA), Perinatal HIV Research Unit (ZA), Joint Clinical Research Centre (UG), University College London (GB), Makerere University (UG), Medical Research Council (GB), University of KwaZulu-Natal (ZA)
ViiV Healthcare, Radboud Universitair Medisch Centrum
Openalex Percentile: Top 9%
HIV/AIDS drug development and treatment
2.79
DOIOpen Access PDFOpenAlex
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