Premorbid functioning trajectories and the one-year course of cognitive performance in first-episode psychosis: a cluster analysis in PSYSCAN
This study confirms a positive association between PMF and cognitive performance in the early years following psychosis onset. It aligns with findings that individuals later diagnosed with schizophrenia already show developmental deficits/lags from childhood to early adolescence compared to normally developing children. As PMF can be considered a proxy for cognitive reserve, our results suggest that higher reserve acts as a buffer against cognitive decline and supports better performance on sustained visual attention, complex visual working memory, and aspects of emotion recognition.
Authors
- Celso Arango (ORCID: https://orcid.org/0000-0003-3382-4754)
- George Gifford (ORCID: https://orcid.org/0000-0002-3133-1019)
- Anke Maatz (ORCID: https://orcid.org/0000-0002-6124-7758)
- Paola Dazzan (ORCID: https://orcid.org/0000-0002-8427-3617)
- Mark Weiser (ORCID: https://orcid.org/0000-0003-3638-0271)
- Thérèse van Amelsvoort (ORCID: https://orcid.org/0000-0003-1135-5133)
- Jun Soo Kwon (ORCID: https://orcid.org/0000-0002-1060-1462)
- Benedicto Crespo‐Facorro (ORCID: https://orcid.org/0000-0003-0033-7132)
- Silvana Galderisi (ORCID: https://orcid.org/0000-0002-1592-7656)
- Margot I. E. Slot (ORCID: https://orcid.org/0000-0003-0420-6922)
- Barnaby Nelson (ORCID: https://orcid.org/0000-0002-6263-2332)
- Lieuwe de Haan (ORCID: https://orcid.org/0000-0002-3820-7926)
- Hendrika H. van Hell
- Birte Yding Glenthoj (ORCID: https://orcid.org/0000-0003-3056-7262)
- Gabriele Sachs (ORCID: https://orcid.org/0000-0002-8359-9877)
- Irina Falkenberg (ORCID: https://orcid.org/0000-0003-3699-0803)
- Philip K. McGuire (ORCID: https://orcid.org/0000-0003-4381-0532)
- Inge Winter-van Rossum
- René S. Kahn
- A. Ter Maat
- Colm McDonald
Institutions
- University of Copenhagen (DK)
- Philipps University of Marburg (DE)
- Tel Aviv University (IL)
- The University of Melbourne (AU)
- King's College London (GB)
- Ollscoil na Gaillimhe – University of Galway (IE)
- University of Campania "Luigi Vanvitelli" (IT)
- University of Zurich (CH)
- Sheba Medical Center (IL)
- Instituto de Salud Carlos III (ES)
- Glostrup Hospital (DK)
- Seoul National University Hospital (KR)
- Warneford Hospital (GB)
- Hospital General Universitario Gregorio Marañón (ES)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- University of Oxford (GB)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Orygen (AU)
- Institute of Behavioral Sciences (JP)
- Instituto de Biomedicina de Sevilla (ES)
- Hospital Universitario Virgen del Rocío (ES)
- Medical University of Vienna (AT)
- University of Amsterdam (NL)
- Anyang University (KR)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Schizophrenia Research Cognition
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.scog.2025.100391
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission