Cholangiocyte-derived exosomal miR-381-3p promotes hepatic stellate cell activation and cholestatic liver fibrosis via targeting Klf6
This study highlighted the role of MLE-derived exosomal miR-381-3p in promoting HSC activation and cholestatic liver fibrosis through the regulation of Klf6. These findings provide novel insights into the molecular mechanisms underlying CCLD.
Authors
- Yuanyi Mang
- Xibing Zhang
- Shengning Zhang (ORCID: https://orcid.org/0000-0001-6133-0132)
- Yonglin Chen (ORCID: https://orcid.org/0009-0008-7419-4481)
- Yang Gao (ORCID: https://orcid.org/0000-0001-5918-4105)
- Xiaoshan Li
Institutions
- Kunming Medical University (CN)
- The First Hospital of Kunming (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.reth.2025.09.008
- Citations
- 1
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.81