Acute 17β-Estradiol Administration Enhances Fear Extinction Memory and Alters Gut Microbiota in Female Rats
The current data suggest that E2-enhanced fear extinction consolidation may be linked to alterations in gut microbiome composition. These findings may reveal a novel potential target for anxiety and other fear-based psychiatric disorders.
Authors
- Brittney N. McMullen (ORCID: https://orcid.org/0000-0002-4958-1358)
- Regina Lamendella (ORCID: https://orcid.org/0000-0002-0952-1326)
- Lisa Y. Maeng (ORCID: https://orcid.org/0000-0001-5122-4301)
- Kayleigh‐Marie Nunez (ORCID: https://orcid.org/0000-0002-4216-659X)
- Karina Silva (ORCID: https://orcid.org/0000-0001-5045-8552)
- Justin Wright (ORCID: https://orcid.org/0000-0002-1132-8349)
- G Walker
- M. I. Joseph
- Cassandra E Hartsgrove (ORCID: https://orcid.org/0009-0006-2083-1276)
- Karina Alejos
Institutions
- Boston University (US)
- University of Massachusetts Boston (US)
- Wright Materials Research (United States) (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100620
- Citations
- 1
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 1.11