<scp>AZP2006</scp> in Progressive Supranuclear Palsy: Outcomes from a Phase 2a Multicenter, Randomized Trial, and Open‐Label Extension on Safety, Biomarkers, and Disease Progression
AZP2006 was well-tolerated and demonstrated favorable trends in biomarker and clinical outcomes. These preliminary signals support further investigation to determine whether a meaningful clinical benefit can be achieved in PSP with AZP2006. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Nicolas Carrière (ORCID: https://orcid.org/0000-0003-3900-5557)
- Jean‐Christophe Corvol (ORCID: https://orcid.org/0000-0001-7325-0199)
- Philippe Verwaerde (ORCID: https://orcid.org/0000-0002-0184-1990)
- Olivier Defert
- Cecilia Estrella
- Mickaël Alexandre Obadia
- Luc Defebvre (ORCID: https://orcid.org/0000-0002-5325-195X)
- David Devos (ORCID: https://orcid.org/0000-0002-2417-799X)
- Graziella Mangone (ORCID: https://orcid.org/0000-0002-2847-3067)
- Noëlle Callizot (ORCID: https://orcid.org/0000-0002-4796-1592)
- Günter U. Höglinger (ORCID: https://orcid.org/0000-0001-7587-6187)
- Aurélien Blondel
- Louise‐Laure Mariani (ORCID: https://orcid.org/0000-0002-2365-1223)
- Caroline Moreau (ORCID: https://orcid.org/0000-0002-5683-2709)
- Artin Karapet
- Jean‐Philippe Brandel
- Sara Sambin (ORCID: https://orcid.org/0000-0002-5027-497X)
- Marie Lebouteux
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Munich Cluster for Systems Neurology (DE)
- Fondation Ophtalmologique Adolphe de Rothschild (FR)
- Fondation de Rothschild (FR)
- Institut de Psychiatrie et Neurosciences de Paris (FR)
- Institut du Cerveau (FR)
- Ludwig-Maximilians-Universität München (DE)
- Evotec (United States) (US)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1002/mds.70049
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00