Ten-Day-Old Neonate Cocaine Exposure and Human Milk: A Case Report

Case reports of lactational intoxications are frequent, especially with drugs, like COC, which can build up in acidic body fluids, like human milk, without the ability to disperse. Development of new biomarkers for early diagnosis of intoxication are needed for substances with toxic potential, such as COC. An increase in activated Partial Thromboplastin Time (aTTP) time may be associated with lactational COC intoxication and may serve as an early biomarker for liver damage. Furthermore, immunochromatography assays serve as alternative screening tools, particularly well-suited for emergency scenarios involving suspected drug exposure, employing biological samples to enable rapid assessment. More studies are needed to assess the influence of COC exposure on coagulation parameters.

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Publication Details

Journal
Journal of Human Lactation
Published
2025-09-27
DOI
https://doi.org/10.1177/08903344251373052
Primary Topic
Prenatal Substance Exposure Effects
Type
article
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article

Ten-Day-Old Neonate Cocaine Exposure and Human Milk: A Case Report

Leonardo Corrêa Cardoso, André Valle de Bairros, Karla Nunes Pereira, Nathalie Michels et al.
Journal of Human Lactation
Prenatal Substance Exposure Effects
article

Ten-Day-Old Neonate Cocaine Exposure and Human Milk: A Case Report

Leonardo Corrêa Cardoso, André Valle de Bairros, Karla Nunes Pereira, Nathalie Michels, Fernanda Ziegler Reginato, Karol Andriely de Vargas Paier, Ana Carolina Kieling
article en

Abstract

Case reports of lactational intoxications are frequent, especially with drugs, like COC, which can build up in acidic body fluids, like human milk, without the ability to disperse. Development of new biomarkers for early diagnosis of intoxication are needed for substances with toxic potential, such as COC. An increase in activated Partial Thromboplastin Time (aTTP) time may be associated with lactational COC intoxication and may serve as an early biomarker for liver damage. Furthermore, immunochromatography assays serve as alternative screening tools, particularly well-suited for emergency scenarios involving suspected drug exposure, employing biological samples to enable rapid assessment. More studies are needed to assess the influence of COC exposure on coagulation parameters.

Journal of Human LactationVol. 41(4)
Universidade Federal de Santa Maria (BR), Hospital Universitário de Santa Maria (BR)
Openalex Percentile: Top 63%
Prenatal Substance Exposure Effects
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