Microbiota of the uterus cavity: pathology and (or) norm

The presence of a normal uterine microbiome is consistent with the general understanding of the existence of a human microbiome, and thus the uterine microbiota likely plays a previously unrecognized role in uterine physiology and in influencing human reproduction. It was determined that the female genital tract contains its own microbiome, which accounts for 9% of the total number of microorganisms. It was noted that the distribution of the microbiome within the female genital tract is very heterogeneous and has certain patterns. The pathophysiological effects of the uterine microbiome on the endometrial epithelium were determined. The factors determining the state of the microflora of the female genital tract were identified. It was concluded that a healthy uterine microbiome can be corrected or restored by using live biotherapeutic products or promoting the growth of these bacteria through diet (prebiotics) in an attempt to improve human health and fertility. In contrast, identification of dysbiotic profiles associated with a specific pathological condition could potentially be used as microbial biomarkers of poor reproductive health.