Ameliorative Effects of High‐Intensity Interval Training (HIIT) and Methylphenidate Against Tramadol‐Induced Cognitive Impairment: The Role of Hippocampal Oxidative Stress
Although both MPH and HIIT interventions show promise in mitigating tramadol-induced cognitive deficits, their mechanisms of action appear to differ significantly. HIIT likely exerts its effects by modulating oxidative stress, whereas MPH seems to disrupt it, suggesting distinct underlying mechanisms. Further studies are required to elucidate these mechanisms in greater detail.
Authors
- Sara Shirazpour
- Mostafa Zangiabadi (ORCID: https://orcid.org/0000-0003-2391-4430)
- Gholamreza Sepehri (ORCID: https://orcid.org/0000-0001-7999-9934)
- Najmeh Sadat Hosseini (ORCID: https://orcid.org/0000-0002-4737-8655)
- Sara Sheikhi (ORCID: https://orcid.org/0000-0002-6259-1286)
- Mohammad Amin Rajizadeh (ORCID: https://orcid.org/0000-0001-6708-1720)
- Farahnaz Taheri (ORCID: https://orcid.org/0000-0002-5361-4466)
- Nazanin Sabet (ORCID: https://orcid.org/0000-0002-9549-6402)
- Manzumeh Shamsi Meymandi (ORCID: https://orcid.org/0000-0002-4011-7364)
- Mahla Zangiabadizadeh
Institutions
- Shahid Bahonar University of Kerman (IR)
- The University of Texas at Arlington (US)
- Kerman University of Medical Sciences (IR)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1002/brb3.70925
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 0.00