Gold‐Catalyzed Conia‐Ene Reaction of Malonate Derivatives Bearing An Alkyne Moiety by Using a Phosphine–Borane Ligand
A gold‐catalyzed Conia‐ene reaction of malonate derivatives is developed by using a phosphine–borane ligand. This catalyst system can be applicable not only for 5‐ exo‐dig ‐mode cyclization reactions but also for 5‐ endo‐dig ‐mode cyclizations. A variety of 2‐(4‐pentynyl)malonates and 2‐(3‐butynyl)malonates afford the corresponding cyclic compounds in moderate to high yields. The boryl enolate might be formed in situ and attacks intramolecularly an alkyne moiety, activated by a gold catalyst, is considered.
Authors
- Gen Onodera (ORCID: https://orcid.org/0000-0003-3082-1638)
- Masanari Kimura (ORCID: https://orcid.org/0000-0003-2900-9554)
- H. Shimizu (ORCID: https://orcid.org/0000-0002-6599-5358)
- Rintaro Kuwahara
- Kaoru Kawasaki (ORCID: https://orcid.org/0000-0003-3359-6755)
- Tsutomu Fukuda (ORCID: https://orcid.org/0000-0002-5400-2808)
- Norbert Krause (ORCID: https://orcid.org/0000-0001-9447-3746)
Institutions
- University of Nagasaki (JP)
- TU Dortmund University (DE)
- Nagasaki University (JP)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1002/adsc.70064
- Citations
- 1
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94