Does sex matter in neurons’ response to hypoxic stress?
In our model of the ischemic penumbra, exogenous estrogen modulated neuronal network activity, with sex-dependent differences evident under normoxic but not hypoxic or recovery conditions. These effects reflect context-dependent responsiveness rather than intrinsic sex differences, and provide no evidence for enhanced neuronal survival after hypoxia.
Authors
- Monica Frega (ORCID: https://orcid.org/0000-0002-9697-3282)
- Jeannette Hofmeijer (ORCID: https://orcid.org/0000-0002-7593-5674)
- Eva J.H.F. Voogd (ORCID: https://orcid.org/0000-0002-2632-3399)
- Marloes Levers
- Michel J. A. M. van Putten (ORCID: https://orcid.org/0000-0001-8319-3626)
Institutions
- Medisch Spectrum Twente (NL)
- Rijnstate Hospital (NL)
- University of Twente (NL)
Publication Details
- Journal
- Journal of Stroke and Cerebrovascular Diseases
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108444
- Citations
- 1
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91