Polygenic predisposition to transdiagnostic symptom dimensions and treatment outcomes across psychiatric disorders
PGSs for cognitive traits showed trait- and diagnosis-specific associations with treatment outcomes. Cross-diagnostic analyses may identify shared genetic influences, but variability in symptom expression across disorders may introduce heterogeneity and reduce the detectability of such effects.
Authors
- Stuart Montgomery (ORCID: https://orcid.org/0000-0002-5983-0063)
- Joseph Zohar (ORCID: https://orcid.org/0000-0002-6925-9104)
- Diana De Ronchi (ORCID: https://orcid.org/0000-0002-2913-0621)
- Paolo Abondio (ORCID: https://orcid.org/0000-0002-9626-8495)
- Panagiotis P. Ferentinos (ORCID: https://orcid.org/0000-0001-8531-5623)
- Julien Mendlewicz (ORCID: https://orcid.org/0000-0002-6131-2732)
- Giuseppe Fanelli (ORCID: https://orcid.org/0000-0001-7930-563X)
- Marco Menchetti (ORCID: https://orcid.org/0000-0003-0553-539X)
- Maria Giulia Bacalini (ORCID: https://orcid.org/0000-0003-1618-2673)
- Chiara Fabbri (ORCID: https://orcid.org/0000-0003-0276-7865)
- Valentina Baldini (ORCID: https://orcid.org/0000-0001-5795-5834)
- Daniel Souery (ORCID: https://orcid.org/0000-0003-3434-5958)
- Alessandro Serretti (ORCID: https://orcid.org/0000-0003-4363-3759)
- Alessio Maria Monteleone (ORCID: https://orcid.org/0000-0002-6786-4458)
- Luigi Grassi (ORCID: https://orcid.org/0000-0002-6308-7540)
- Gianluigi Forloni (ORCID: https://orcid.org/0000-0001-5374-3914)
- Siegfried Kasper (ORCID: https://orcid.org/0000-0002-9327-2843)
- Diego Albani (ORCID: https://orcid.org/0000-0002-7050-6723)
- Dan Rujescu
- Anna Rita Atti
Institutions
- University of Modena and Reggio Emilia (IT)
- Université Libre de Bruxelles (BE)
- Radboud University Nijmegen (NL)
- Mario Negri Institute for Pharmacological Research (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- University of Ferrara (IT)
- Università degli Studi di Enna Kore (IT)
- Sheba Medical Center (IL)
- European Research Council (BE)
- Radboud University Medical Center (NL)
- Oasi Maria SS (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Imperial College London (GB)
- Medical University of Vienna (AT)
- University of Bologna (IT)
Publication Details
- Journal
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.pnpbp.2025.111512
- Primary Topic
- Mental Health Research Topics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- Massachusetts General Hospital
- H. Lundbeck A/S
- National Institutes of Health
- National Institute of Mental Health