Identity, functional consequences, and context effects of amino acids inserted during suppression of CFTR nonsense mutations
Nonsense suppression therapy shows promise as a treatment for CF patients who carry a PTC, especially when combined with current CFTR modulators. Mechanistic insights of readthrough gleaned from this study can be used to develop better therapeutic strategies for treating CF patients who carry a nonsense mutation.
Authors
- Steven M. Rowe (ORCID: https://orcid.org/0000-0001-9045-0133)
- Jens‐Ola Ekström
- Lianwu Fu
- Matthew B. Renfrow (ORCID: https://orcid.org/0000-0002-4193-7305)
- David M. Bedwell (ORCID: https://orcid.org/0000-0002-6605-818X)
- Audra A. Hargett (ORCID: https://orcid.org/0000-0002-0459-1392)
- K. Thrasher (ORCID: https://orcid.org/0000-0003-0281-1686)
- Kim M. Keeling (ORCID: https://orcid.org/0000-0003-0471-5858)
- D. Woodrow Benson (ORCID: https://orcid.org/0000-0002-1134-1973)
- Jianguo Chen (ORCID: https://orcid.org/0000-0003-0424-1875)
Institutions
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Journal of Cystic Fibrosis
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.jcf.2025.09.006
- Citations
- 2
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Institutes of Health