Dax1 in AgRP neurons regulates thermogenesis via GR-HDAC3-mediated CRFR1 suppression
Our findings establish Dax1 as a critical transcriptional repressor of Crfr1 in AgRP neurons, linking hypothalamic steroid signaling to the regulation of adaptive thermogenesis and systemic energy balance.
Authors
- Jeong‐Heon Cha (ORCID: https://orcid.org/0000-0002-9385-2653)
- Zhiyang Wei (ORCID: https://orcid.org/0000-0002-7791-4826)
- Seunghee Lee (ORCID: https://orcid.org/0000-0001-5483-0016)
Institutions
- Seoul National University (KR)
- New Generation University College (ET)
- National University College (PR)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.molmet.2025.102258
- Citations
- 1
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 1.29