A custom preservation solution extends the ex vivo availability of living heart valves for transplantation
Normothermic preservation of living valves can support tissue viability for at least 7 weeks ex vivo. With additional preclinical validation, stored living valves could act as a tissue source for heart valve transplantation, with key advantages in enhanced availability and resource-efficiency.
Authors
- Emmanuel Zorn (ORCID: https://orcid.org/0000-0001-9985-8389)
- Şenay Üstünel (ORCID: https://orcid.org/0000-0001-7860-3870)
- Elizabeth M. Cordoves (ORCID: https://orcid.org/0000-0002-4546-0743)
- David M. Kalfa (ORCID: https://orcid.org/0000-0003-4324-6038)
- Kavya Rajesh (ORCID: https://orcid.org/0000-0002-4180-5118)
- Sharon Fleischer (ORCID: https://orcid.org/0000-0002-9852-6697)
- Richard Zhuang
- Keith Yeager (ORCID: https://orcid.org/0000-0002-1897-9320)
- Gordana Vunjak‐Novakovic (ORCID: https://orcid.org/0000-0002-9382-1574)
- V. Reed LaSala (ORCID: https://orcid.org/0000-0001-8600-7219)
- Giovanni Ferrari
- Emile Bacha (ORCID: https://orcid.org/0000-0002-7925-848X)
- N Fàbregas Julià
- Sophia Jackman
- B. Liu (ORCID: https://orcid.org/0000-0002-3006-5564)
- Olivier Pont
- Griffin Welsh Daly
- Lucie Chicaud
Institutions
- Morgan Stanley Children's Hospital (US)
- Columbia University Irving Medical Center (US)
- Columbia University (US)
Publication Details
- Journal
- JTCVS Open
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.xjon.2025.08.019
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00