Codon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation
Together, these findings suggest that differential ribosome stalling under branched-chain amino acid starvation reflects a balance between amino acid supply, tRNA charging dynamics, codon position, and stress-response signaling.
Authors
- Cédric Gobet (ORCID: https://orcid.org/0000-0001-5627-3444)
- Lina Worpenberg
- Félix Naef (ORCID: https://orcid.org/0000-0001-9786-3037)
Institutions
- École Polytechnique Fédérale de Lausanne (CH)
Publication Details
- Journal
- Genome biology
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1186/s13059-025-03800-6
- Citations
- 6
- Primary Topic
- RNA and protein synthesis mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Science Foundation
- École Polytechnique Fédérale de Lausanne
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Université de Lausanne