Phentolamine: more than just an adrenergic blocker – a pathway to a potential analgesic?
Phentolamine, a non-selective α-adrenergic antagonist traditionally used for vascular conditions and local anesthetic reversal, may have properties as a modulator of pain pathways. In this study[1][1] using ex vivo preparations from mice, pigs, and humans, phentolamine decreased compound action
Authors
- Ryan S. D’Souza (ORCID: https://orcid.org/0000-0002-4601-9837)
- Siegfried Engler
- Hipólito Labandeyra (ORCID: https://orcid.org/0000-0002-1379-2516)
Institutions
- Mayo Clinic (US)
- Delfos Hospital (ES)
- Universitat de Barcelona (ES)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Regional Anesthesia & Pain Medicine
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1136/rapm-2025-107193
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00