Baseline hemoglobin and neutrophil-to-lymphocyte ratio as prognostic biomarkers in patients with metastatic triple negative breast cancer treated with sacituzumab govitecan in second line and beyond: a real-world analysis
Baseline Hb and NLR were identified as independent prognostic biomarkers in patients with mTNBC receiving SG treatment, predicting PFS and OS, respectively. Other inflammatory indices (PLR, SII) did not demonstrate prognostic relevance. Prospective validation in larger cohorts is essential to confirm these findings and potentially guide personalized treatment strategies.
Authors
- Jakub Wronowicz (ORCID: https://orcid.org/0000-0002-1454-2068)
- Michał Jarząb (ORCID: https://orcid.org/0000-0002-2642-9724)
- Małgorzata Pieniążek (ORCID: https://orcid.org/0000-0001-5864-0877)
- Aleksandra Łacko
- Manuela Las‐Jankowska (ORCID: https://orcid.org/0000-0002-3970-0368)
- Anna Polakiewicz-Gilowska (ORCID: https://orcid.org/0000-0002-2175-7067)
- Mirosława Püsküllüoğlu (ORCID: https://orcid.org/0000-0002-2647-9625)
Institutions
- Nicolaus Copernicus University (PL)
- Wroclaw Medical University (PL)
- Comprehensive Cancer Center Vienna (AT)
- University of Bydgoszcz (PL)
- Greater Poland Cancer Center (PL)
- National Institute of Oncology (HU)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
Publication Details
- Journal
- Breast Cancer Research and Treatment
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1007/s10549-025-07825-0
- Citations
- 1
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.05