Real‐World Molecular Testing in European Early‐Onset Colorectal Cancer
Our results support universal and paired somatic and germline multi-gene panels for all EOCRC patients, regardless of MMR status or family history. Systematic molecular testing approaches are necessary to address disparities in people with EOCRC. Larger unselected cohort studies would support validation of testing prediction models and estimates of clinically relevant variant actionability.
Authors
- Carlos Pastor Idoate (ORCID: https://orcid.org/0000-0002-1273-9326)
- Fernando Jiménez Escovar (ORCID: https://orcid.org/0000-0003-3672-648X)
- Araceli Ballestero (ORCID: https://orcid.org/0000-0002-4897-2154)
- José Perea (ORCID: https://orcid.org/0000-0001-5522-8844)
- Nikhil Pawa (ORCID: https://orcid.org/0000-0003-2122-0830)
- Andrew R. Latchford (ORCID: https://orcid.org/0000-0002-8626-188X)
- Damián García‐Olmo (ORCID: https://orcid.org/0000-0002-9369-2338)
- Rogelio González‐Sarmiento (ORCID: https://orcid.org/0000-0002-2726-6795)
- Antonino Spinelli (ORCID: https://orcid.org/0000-0002-1493-1768)
- Robert Hüneburg (ORCID: https://orcid.org/0000-0001-9957-8299)
- Edurne Álvaro (ORCID: https://orcid.org/0000-0001-6793-3188)
- Lorena Brandáriz (ORCID: https://orcid.org/0000-0003-0228-9461)
- Penelope Edwards (ORCID: https://orcid.org/0000-0003-3244-8902)
- Francesc Balaguer (ORCID: https://orcid.org/0000-0002-0206-0539)
- Caterina Foppa (ORCID: https://orcid.org/0000-0001-9920-0368)
- Kevin John Monahan (ORCID: https://orcid.org/0000-0002-7918-4003)
- José A. Rueda (ORCID: https://orcid.org/0000-0003-3558-3755)
- Marta Jiménez‐Toscano (ORCID: https://orcid.org/0000-0002-5970-426X)
- Jacob Nattermann (ORCID: https://orcid.org/0000-0001-5972-0780)
- Irene López
- Huw Thomas (ORCID: https://orcid.org/0000-0002-6465-229X)
- Omar Faiz (ORCID: https://orcid.org/0000-0003-1117-1588)
- Andreana N. Holowatyj (ORCID: https://orcid.org/0000-0001-8001-8793)
- Noel F. F. C. de Miranda
- Terri Patricia McVeigh (ORCID: https://orcid.org/0000-0001-9201-9216)
- Cristina Viyuela
- Marc Martí (ORCID: https://orcid.org/0000-0001-6189-2178)
- Andrew George (ORCID: https://orcid.org/0000-0002-6261-6711)
- Gonzalo Sanz
- Elena Hurtado (ORCID: https://orcid.org/0000-0002-1955-261X)
- F. Liccardo (ORCID: https://orcid.org/0000-0002-1054-1316)
- Kussai Giuma Ali Eloussta
Institutions
- Leiden University (NL)
- Hebron University (PS)
- Royal Marsden NHS Foundation Trust (GB)
- Humanitas University (IT)
- Universidad de Salamanca (ES)
- University Hospital Bonn (DE)
- Chelsea and Westminster Hospital NHS Foundation Trust (GB)
- Leiden University Medical Center (NL)
- Hospital General Universitario Gregorio Marañón (ES)
- Hospital Clínico San Carlos (ES)
- Hospital Universitario Fundación Alcorcón (ES)
- Hospital Universitario Araba (ES)
- Hospital Clínic de Barcelona (ES)
- Hospital de Galdakao (ES)
- Royal Marsden Hospital (GB)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital General Universitario De Valencia (ES)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Hospital Del Mar (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Instituto de Investigación Biomédica de Salamanca (ES)
- Clinica Universidad de Navarra (ES)
- Centro de Investigación del Cáncer (ES)
- MD Anderson Cancer Center Madrid (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- St Mark's Hospital (GB)
- Hospital Universitario Ramón y Cajal (ES)
- IRCCS Humanitas Research Hospital (IT)
- Hospital Universitario Infanta Leonor (ES)
- Imperial College London (GB)
- Universitat de Barcelona (ES)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- United European Gastroenterology Journal
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1002/ueg2.70112
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Instituto de Salud Carlos III
- European Regional Development Fund