Resolution in Two-Photon Imaging: A Local Manifestation of Entanglement
The resolution of a classical imaging system is limited by diffraction. This limit can be overcome, for example, by implementing various forms of localization microscopy in which the center of a fluorescence distribution is estimated to an accuracy scaling with the square root of the number of detected photons, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msqrt><mml:mi>N</mml:mi></mml:msqrt> </mml:math> . In quantum imaging the object can be illuminated using correlated photon-pairs, leading early work to suggest that a <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msqrt><mml:mn>2</mml:mn></mml:msqrt> </mml:math> improvement could be obtained as a result of averaging the position of <i>N</i> = 2 events. However, similar to quantum lithography, which relies upon quantum illumination using entangled photon-pairs and two-photon absorption, the minimum resolvable feature size is reduced by a factor of 2, not just <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msqrt><mml:mn>2</mml:mn></mml:msqrt> </mml:math> . Quantum imaging schemes can also lead to a factor of 2 improvement. By using a similar source of correlated photon-pairs to illuminate an object, a single-photon sensitive camera to detect the photon-pairs, and an image processing algorithm to record and sum the bisector positions of the transmitted photon-pairs, we realize a similar factor of ×2 improvement in image resolution, surpassing that of most earlier quantum imaging work.
Authors
- Miles J. Padgett (ORCID: https://orcid.org/0000-0001-6643-0618)
- Osian Wolley (ORCID: https://orcid.org/0000-0002-1016-9796)
- Ermes Toninelli
- Paul‐Antoine Moreau (ORCID: https://orcid.org/0000-0001-7628-5821)
- Simon Peter Mekhail (ORCID: https://orcid.org/0000-0003-4775-4208)
- Jakub Bělín (ORCID: https://orcid.org/0000-0002-8801-1606)
- Thomas Gregory (ORCID: https://orcid.org/0000-0001-9376-6790)
- Stephen M. Barnett (ORCID: https://orcid.org/0000-0003-0733-4524)
- Kim Roberts
Institutions
- Central European Institute of Technology (CZ)
- Cambridge Consultants (United Kingdom) (GB)
- Brno University of Technology (CZ)
- University of Glasgow (GB)
- National Cheng Kung University (TW)
Publication Details
- Journal
- ACS Photonics
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1021/acsphotonics.5c01310
- Primary Topic
- Advanced Fluorescence Microscopy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00