Resolution in Two-Photon Imaging: A Local Manifestation of Entanglement

The resolution of a classical imaging system is limited by diffraction. This limit can be overcome, for example, by implementing various forms of localization microscopy in which the center of a fluorescence distribution is estimated to an accuracy scaling with the square root of the number of detected photons, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msqrt><mml:mi>N</mml:mi></mml:msqrt> </mml:math> . In quantum imaging the object can be illuminated using correlated photon-pairs, leading early work to suggest that a <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msqrt><mml:mn>2</mml:mn></mml:msqrt> </mml:math> improvement could be obtained as a result of averaging the position of <i>N</i> = 2 events. However, similar to quantum lithography, which relies upon quantum illumination using entangled photon-pairs and two-photon absorption, the minimum resolvable feature size is reduced by a factor of 2, not just <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msqrt><mml:mn>2</mml:mn></mml:msqrt> </mml:math> . Quantum imaging schemes can also lead to a factor of 2 improvement. By using a similar source of correlated photon-pairs to illuminate an object, a single-photon sensitive camera to detect the photon-pairs, and an image processing algorithm to record and sum the bisector positions of the transmitted photon-pairs, we realize a similar factor of ×2 improvement in image resolution, surpassing that of most earlier quantum imaging work.

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Publication Details

Journal
ACS Photonics
Published
2025-09-27
DOI
https://doi.org/10.1021/acsphotonics.5c01310
Primary Topic
Advanced Fluorescence Microscopy Techniques
Type
article
Field-Weighted Citation Impact
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article

Resolution in Two-Photon Imaging: A Local Manifestation of Entanglement

Miles J. Padgett, Osian Wolley, Ermes Toninelli, Paul‐Antoine Moreau et al.
ACS Photonics
Advanced Fluorescence Microscopy Techniques
article

Resolution in Two-Photon Imaging: A Local Manifestation of Entanglement

Miles J. Padgett, Osian Wolley, Ermes Toninelli, Paul‐Antoine Moreau, Simon Peter Mekhail, Jakub Bělín, Thomas Gregory, Stephen M. Barnett, Kim Roberts
article en

Abstract

The resolution of a classical imaging system is limited by diffraction. This limit can be overcome, for example, by implementing various forms of localization microscopy in which the center of a fluorescence distribution is estimated to an accuracy scaling with the square root of the number of detected photons, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msqrt><mml:mi>N</mml:mi></mml:msqrt> </mml:math> . In quantum imaging the object can be illuminated using correlated photon-pairs, leading early work to suggest that a <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msqrt><mml:mn>2</mml:mn></mml:msqrt> </mml:math> improvement could be obtained as a result of averaging the position of <i>N</i> = 2 events. However, similar to quantum lithography, which relies upon quantum illumination using entangled photon-pairs and two-photon absorption, the minimum resolvable feature size is reduced by a factor of 2, not just <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msqrt><mml:mn>2</mml:mn></mml:msqrt> </mml:math> . Quantum imaging schemes can also lead to a factor of 2 improvement. By using a similar source of correlated photon-pairs to illuminate an object, a single-photon sensitive camera to detect the photon-pairs, and an image processing algorithm to record and sum the bisector positions of the transmitted photon-pairs, we realize a similar factor of ×2 improvement in image resolution, surpassing that of most earlier quantum imaging work.

ACS PhotonicsVol. 12(10)
Central European Institute of Technology (CZ), Cambridge Consultants (United Kingdom) (GB), Brno University of Technology (CZ), University of Glasgow (GB), National Cheng Kung University (TW)
Openalex Percentile: Top 81%
Advanced Fluorescence Microscopy Techniques
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