Features of Carbapenem-resistant Gram-negative Bacterial Infections in Japan Based on the Setting of Onset
Community-associated CR-GNB infections are an emerging concern in Japan, showing distinct pathogen profiles and infection sites compared to HO cases. Importantly, HA infections resembled CA infections in terms of clinical characteristics and outcomes, suggesting a need to reexamine the clinical relevance of current HA classification criteria for guiding therapy and risk stratification.
Authors
- Kayoko Hayakawa (ORCID: https://orcid.org/0000-0002-5480-4405)
- Momoko Mawatari (ORCID: https://orcid.org/0000-0002-8953-5962)
- Yohei Doi (ORCID: https://orcid.org/0000-0002-9620-2525)
- Kohei Uemura
- Yasufumi Matsumura (ORCID: https://orcid.org/0000-0001-8595-8944)
- Masahiro Suzuki (ORCID: https://orcid.org/0000-0003-4550-3499)
- Naoya Itoh (ORCID: https://orcid.org/0000-0001-6269-7884)
- Tetsuya Suzuki (ORCID: https://orcid.org/0000-0003-3165-9062)
- Takashi Matono (ORCID: https://orcid.org/0000-0001-9957-0510)
- Koji Ohyama (ORCID: https://orcid.org/0000-0002-8472-0413)
- Ryota Hase (ORCID: https://orcid.org/0000-0002-3135-1757)
- Yusuke Asai (ORCID: https://orcid.org/0000-0003-2979-3449)
- Sho Saito
- Norio Ohmagari (ORCID: https://orcid.org/0000-0002-4622-8970)
- David van Duin (ORCID: https://orcid.org/0000-0003-4784-3227)
- Takeya Tsutsumi (ORCID: https://orcid.org/0000-0003-0851-1887)
- Aki Sakurai (ORCID: https://orcid.org/0000-0003-2198-8954)
- Hideaki Kato (ORCID: https://orcid.org/0000-0002-7853-5721)
- Go Yamamoto (ORCID: https://orcid.org/0000-0001-9229-2976)
- Shinya Tsuzuki
- Takehiro Hashimoto
- Yuya Kawamoto
Institutions
- University of North Carolina at Chapel Hill (US)
- Fujita Health University (JP)
- University of Pittsburgh (US)
- Saga University (JP)
- Kyoto University (JP)
- Nagoya City University (JP)
- National Center for Global Health and Medicine (JP)
- Yokohama City University Hospital (JP)
- Japanese Red Cross Medical Center (JP)
- University of Tokyo Hospital (JP)
- University of Yamanashi Hospital (JP)
- Center for Global Health (US)
- Institute for Health Economics and Policy (JP)
- Japanese Red Cross Narita Hospital (JP)
- Aso Iizuka Hospital (JP)
- Oita University Hospital (JP)
- Osaka University Hospital (JP)
- Osaka City University Hospital (JP)
- The University of Tokyo (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1093/ofid/ofaf585
- Primary Topic
- Infections and bacterial resistance
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pfizer
- Gilead Sciences
- British Society for Antimicrobial Chemotherapy
- Meiji Seika Pharma
- Shionogi
- National Institutes of Health
- Chugai Pharmaceutical
- Daiichi Sankyo Europe