Simultaneous Quantification of Azole Antimycotics in Quantitative Dried Blood Spots: A Step Toward Home Sampling for Therapeutic Drug Monitoring
This study established a sensitive, accurate, precise, and robust quantification method in qDBS samples containing only 10 μL of whole blood. Stability tests showed that samples could be safely mailed, offering a cheaper alternative to cold chain logistics. A conversion formula using routine TDM samples was developed, providing a straightforward and cost-effective approach for establishing a conversion formula that is potentially applicable to other TDM analytes. This study represents an in vitro analytical validation, and future clinical research is needed to translate the analytical method from bench to bedside.
Authors
- Hengjie Yuan (ORCID: https://orcid.org/0000-0001-7132-5572)
- Lan Su (ORCID: https://orcid.org/0000-0002-8692-3310)
- Wanqing Yao (ORCID: https://orcid.org/0000-0003-4394-4469)
- Zeng-Xuan Cai
- Pei Luo (ORCID: https://orcid.org/0000-0002-8983-9229)
- Jinghua Yuan (ORCID: https://orcid.org/0000-0002-0274-9512)
- Qi Chen (ORCID: https://orcid.org/0000-0002-5152-0079)
- Junlin Wang (ORCID: https://orcid.org/0009-0002-3715-1980)
- Shengbin Li (ORCID: https://orcid.org/0009-0000-4357-9954)
- Boyu Liu (ORCID: https://orcid.org/0000-0001-5645-005X)
- Xie Yizheng
- Hou Xiaoran
Institutions
- Peking University (CN)
- Tianjin Medical University General Hospital (CN)
- Peking University People's Hospital (CN)
- Zhejiang Shuren University (CN)
- Zhejiang Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1097/ftd.0000000000001352
- Citations
- 1
- Primary Topic
- Biosimilars and Bioanalytical Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.80