Second-Generation Catalyst System for Ag-Mediated Liebeskind-Srogl Coupling of Tetrazine Thioethers with Arylboronic Acids.
An improved catalyst system, PdI<sub>2</sub>/DiPPF, is described for the silver-mediated Liebeskind-Srogl coupling of thioalkyltetrazines with arylboronic and heteroarylboronic acids. The methodology advances the synthesis of functionalized tetrazines, offering greater efficiency, broader compatibility, and practical utility for accessing tool molecules for bioorthogonal chemistry applications.
Authors
- W. Marcus Lambert (ORCID: https://orcid.org/0000-0002-4592-5176)
- Joseph M. Fox (ORCID: https://orcid.org/0000-0002-8258-1640)
- Christopher W. am Ende (ORCID: https://orcid.org/0000-0001-8832-9641)
- Stephanie Tsang
- Chuanqi Wang
- Ashlyn S. Hillman
Institutions
- Pfizer (United States) (US)
- University of Delaware (US)
Publication Details
- Journal
- PubMed
- Published
- 2025-10-10
- DOI
- https://doi.org/10.1021/acs.joc.5c01314
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00