2025 AHA/ACC Statement on Cost/Value Methodology in Clinical Practice Guidelines (Update From 2014 Statement)
This Cost/Value Methodology Statement updates prior guidance regarding the incorporation of evidence from published CEAs into clinical guidelines. It provides guidance for identifying and synthesizing relevant high-quality evidence, developing economic value statements, and communicating level of certainty in such statements. It defines the US cost-effectiveness threshold as $120,000 per quality-adjusted life year gained, highlights special considerations related to cardiovascular drugs and devices, emphasizes health equity considerations when interpreting CEAs, and defines a reference case for future CEAs.
Authors
- Dhruv S Kazi
- Inmaculada Hernandez (ORCID: https://orcid.org/0000-0002-0118-4986)
- Karen E. Joynt Maddox (ORCID: https://orcid.org/0000-0003-3779-8653)
- Kendra D. Sims (ORCID: https://orcid.org/0000-0002-6740-3002)
- Merilyn S. Varghese (ORCID: https://orcid.org/0000-0003-1121-7566)
- Derek S. Chew (ORCID: https://orcid.org/0000-0003-3539-7485)
- Paul A. Heidenreich (ORCID: https://orcid.org/0000-0001-7730-8490)
- Anirban Basu (ORCID: https://orcid.org/0000-0003-4238-7402)
- Colette DeJong (ORCID: https://orcid.org/0000-0003-0514-3193)
- Suzanne V. Arnold (ORCID: https://orcid.org/0000-0003-3367-0302)
- Khadijah Breathett (ORCID: https://orcid.org/0000-0001-5397-6419)
- Brandon Kyle Bellows (ORCID: https://orcid.org/0000-0003-1395-6047)
- Ann Marie Návar (ORCID: https://orcid.org/0000-0002-6197-9860)
- Liesl Zühlke (ORCID: https://orcid.org/0000-0003-3961-2760)
- Apurvakumar Pandya (ORCID: https://orcid.org/0000-0003-0178-3978)
- Nicolás Isaza (ORCID: https://orcid.org/0000-0002-9915-1831)
- Abdul R. Abdullah
- David J. Cohen
- Susan Hennessy (ORCID: https://orcid.org/0000-0002-6342-7138)
Publication Details
- Journal
- Journal of the American College of Cardiology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1016/j.jacc.2025.05.009
- Citations
- 3
- Primary Topic
- Clinical practice guidelines implementation
- Type
- article
- Field-Weighted Citation Impact
- 5.64