Associations Between Structural Phenotype and Polygenic Risk Scores in Intermediate Age-Related Macular Degeneration – A MACUSTAR Report
Our findings reveal subgroups in iAMD based on genotype-phenotype associations which can help identifying patients at high risk for iAMD and establish new endpoints for clinical trials in iAMD.
Authors
- Davide Garzone (ORCID: https://orcid.org/0000-0001-6209-117X)
- Hannah Klinkhammer (ORCID: https://orcid.org/0000-0003-3752-1275)
- Matthias Schmid (ORCID: https://orcid.org/0000-0002-0788-0317)
- Marlene Saßmannshausen (ORCID: https://orcid.org/0000-0001-5265-4645)
- Sergio Leal
- Sarah Thiele (ORCID: https://orcid.org/0000-0002-1123-6700)
- Charlotte Behning (ORCID: https://orcid.org/0000-0002-9310-3804)
- Ulrich F. O. Luhmann (ORCID: https://orcid.org/0000-0002-1993-1951)
- Jan Henrik Terheyden (ORCID: https://orcid.org/0000-0002-0174-4066)
- Robert Patrick Finger (ORCID: https://orcid.org/0000-0003-4253-7597)
- Carel B. Hoyng (ORCID: https://orcid.org/0000-0002-1358-5963)
- H. Floyd
- Clara I. Sánchez
- Lukas Schloesser (ORCID: https://orcid.org/0009-0000-5065-3913)
- Frank G Holz
- Steffen Schmitz‐Valckenberg
Institutions
- Roche (Switzerland) (CH)
- Novartis (Switzerland) (CH)
- University of Bonn (DE)
- Universität Hamburg (DE)
- University of Utah (US)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Zimmer Biomet (Germany) (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Nijmegen Institute for Scientist Practitioners in Addiction (NL)
- Bayer (Switzerland) (CH)
- University Medical Centre Mannheim (DE)
- Phillips University (US)
- University of Amsterdam (NL)
Publication Details
- Journal
- Translational Vision Science & Technology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1167/tvst.14.9.37
- Citations
- 2
- Primary Topic
- Cardiovascular Health and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Biogen
- Alexion Pharmaceuticals
- European Federation of Pharmaceutical Industries and Associations
- Alimera Sciences
- Apellis Pharmaceuticals
- European Commission
- Carl Zeiss Meditec AG
- Astellas Pharma
- Heidelberg Engineering
- Genentech
- Allergan