The activity of immune checkpoint inhibitors in patients with recurrent cervical cancer developed in previously irradiated field: clinical and immunohistochemical investigations
In-field cervical cancer recurrence was associated with decreased sensitivity to ICIs-containing chemotherapies when compared to out-of-field diseases. Decreased tumor-infiltrating CD8⁺ T lymphocytes and PD-L1 expression are possible reasons for this differential sensitivity to ICI-containing chemotherapies.
Authors
- Harumi Nakamura (ORCID: https://orcid.org/0000-0003-4476-8794)
- Michihide Maeda (ORCID: https://orcid.org/0000-0001-8698-8520)
- Seiji Mabuchi (ORCID: https://orcid.org/0000-0003-1803-1166)
- Naoko Komura
- Takeshi Yokoi
- Tomoko Ueda (ORCID: https://orcid.org/0000-0002-1392-2739)
- S Koyama
Institutions
- Osaka Police Hospital (JP)
- Osaka International Cancer Institute (JP)
- Takarazuka City Hospital (JP)
- Hyogo University (JP)
Publication Details
- Journal
- Journal of Gynecologic Oncology
- Published
- 2025-09-22
- DOI
- https://doi.org/10.3802/jgo.2026.37.e13
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00