Multi-omics analysis reveals the prognostic value and immunomodulatory role of CTSW in breast cancer

This study underscores the pivotal role of CTSW in breast cancer immunology, positioning it as a key indicator of a potent anti-tumor immune response within the TME. Collectively, our findings establish a robust, data-driven hypothesis that CTSW's high expression, particularly in TNBC, reflects a favorable, functionally active immune state. This comprehensive in silico investigation substantiates CTSW's potential as a prognostic biomarker and provides a strong rationale for its future experimental validation as a therapeutic target.

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Publication Details

Journal
Discover Oncology
Published
2025-09-26
DOI
https://doi.org/10.1007/s12672-025-03550-8
Citations
1
Primary Topic
Cell Adhesion Molecules Research
Type
article
Field-Weighted Citation Impact
1.62

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article

Multi-omics analysis reveals the prognostic value and immunomodulatory role of CTSW in breast cancer

Jiakai Mao, Pengcheng Xi, Jason Liu, Liming Wang et al.
1 citations
Discover Oncology
Cell Adhesion Molecules Research
1.62
article

Multi-omics analysis reveals the prognostic value and immunomodulatory role of CTSW in breast cancer

Jiakai Mao, Pengcheng Xi, Jason Liu, Liming Wang, Zeli Yin
article en
1 citations

Abstract

This study underscores the pivotal role of CTSW in breast cancer immunology, positioning it as a key indicator of a potent anti-tumor immune response within the TME. Collectively, our findings establish a robust, data-driven hypothesis that CTSW's high expression, particularly in TNBC, reflects a favorable, functionally active immune state. This comprehensive in silico investigation substantiates CTSW's potential as a prognostic biomarker and provides a strong rationale for its future experimental validation as a therapeutic target.

Discover OncologyVol. 16(1)
Dalian Medical University (CN), Second Affiliated Hospital of Dalian Medical University (CN)
National Natural Science Foundation of China, Chinese Academy of Sciences, Dalian Medical University, Dalian Institute of Chemical Physics
Openalex Percentile: Top 15%
Cell Adhesion Molecules Research
1.62
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