Multi-omics analysis reveals the prognostic value and immunomodulatory role of CTSW in breast cancer
This study underscores the pivotal role of CTSW in breast cancer immunology, positioning it as a key indicator of a potent anti-tumor immune response within the TME. Collectively, our findings establish a robust, data-driven hypothesis that CTSW's high expression, particularly in TNBC, reflects a favorable, functionally active immune state. This comprehensive in silico investigation substantiates CTSW's potential as a prognostic biomarker and provides a strong rationale for its future experimental validation as a therapeutic target.
Authors
- Jiakai Mao
- Pengcheng Xi (ORCID: https://orcid.org/0000-0003-3236-5234)
- Jason Liu (ORCID: https://orcid.org/0000-0001-8222-4013)
- Liming Wang (ORCID: https://orcid.org/0000-0003-0914-6113)
- Zeli Yin
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1007/s12672-025-03550-8
- Citations
- 1
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 1.62
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Dalian Medical University
- Dalian Institute of Chemical Physics