Timing and Safety of Anticoagulation Reinitiation After Intracranial Hemorrhage in Patients With Mechanical Valves
In patients with MHVs who experienced an ICH, this meta-analysis found that resumption of AC was associated with a recurrent ICH rate of 11.4% and an ischemic stroke rate of 6.1% during AC suspension. Meta-regression suggested a lower risk of recurrent ICH with later AC resumption, with a potential risk reduction at approximately 11 days after ICH. No time-dependent increase in ischemic stroke was observed. Limitations include the retrospective design of most studies and heterogeneous AC timing across cohorts.
Authors
- Lucio D’Anna (ORCID: https://orcid.org/0000-0002-4349-3322)
- Liqun Zhang (ORCID: https://orcid.org/0000-0001-6983-7915)
- Prapa Kanagaratnam (ORCID: https://orcid.org/0000-0003-3593-2185)
- Marta Gigli (ORCID: https://orcid.org/0000-0002-3856-937X)
- Byung Gun Lim (ORCID: https://orcid.org/0000-0002-3302-1831)
- Maurizio Paciaroni (ORCID: https://orcid.org/0000-0002-5483-8795)
- Roland C. Veltkamp (ORCID: https://orcid.org/0000-0002-0583-1300)
- Mariarosaria Valente (ORCID: https://orcid.org/0000-0001-6077-1315)
- Diana A. Gorog (ORCID: https://orcid.org/0000-0002-9286-1451)
- Eleni Korompoki (ORCID: https://orcid.org/0000-0003-0403-8316)
- Giovanni Merlino (ORCID: https://orcid.org/0000-0002-6525-9529)
- Simona Sacco (ORCID: https://orcid.org/0000-0003-0651-1939)
- Edoardo Pirera (ORCID: https://orcid.org/0000-0003-3011-7405)
- Matteo Foschi (ORCID: https://orcid.org/0000-0002-0321-7155)
- Robert Simister (ORCID: https://orcid.org/0000-0003-0578-6711)
- Gian Luigi Gigli (ORCID: https://orcid.org/0000-0003-3526-1414)
- Francesco Favruzzo (ORCID: https://orcid.org/0000-0001-8548-6027)
- Gabriele Prandin (ORCID: https://orcid.org/0000-0002-5698-4737)
Institutions
- University College Hospital (GB)
- University of Udine (IT)
- University of Hertfordshire (GB)
- University of Trieste (IT)
- Imperial College Healthcare NHS Trust (GB)
- St George's, University of London (GB)
- National and Kapodistrian University of Athens (GR)
- University of Ferrara (IT)
- Heidelberg University (DE)
- University of L'Aquila (IT)
- Hammersmith Hospital (GB)
- University Hospital Heidelberg (DE)
- Charing Cross Hospital (GB)
- Lung Institute (US)
- Department of Health (ES)
- Ospedale dell' Angelo (IT)
- Alfried Krupp Hospital (DE)
- Azienda Sanitaria Universitaria Integrata di Trieste (IT)
- University College London (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Neurology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1212/wnl.0000000000214184
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University College London Hospitals NHS Foundation Trust