Suboptimal ART adherence, undetectable urine tenofovir, and higher C-reactive protein values
Even with antiretroviral therapy, people with HIV often face residual immune activation and chronic systemic inflammation, heightening their risk for early-onset comorbidities such as cardiovascular disease. In a study of 492 men who have sex with men, suboptimal ART adherence, measured by undetectable urine tenofovir, was directly associated with elevated C-reactive protein, even after adjusting for viral suppression and stimulant use. These findings highlight the importance of adherence monitoring to reduce inflammation-related chronic health outcomes.
Authors
- Sabina Hirshfield (ORCID: https://orcid.org/0000-0002-2649-469X)
- Keith J. Horvath (ORCID: https://orcid.org/0000-0001-7569-2839)
- Matthew A. Spinelli (ORCID: https://orcid.org/0000-0001-6368-8664)
- Christian Grov (ORCID: https://orcid.org/0000-0001-6871-3531)
- David V. Glidden (ORCID: https://orcid.org/0000-0001-5888-1419)
- Megan J. Heise (ORCID: https://orcid.org/0000-0001-6651-2381)
- Delaram Ghanooni (ORCID: https://orcid.org/0000-0003-2340-9573)
- Dustin T. Duncan (ORCID: https://orcid.org/0000-0001-8586-8711)
- Adam W. Carrico (ORCID: https://orcid.org/0000-0002-8146-5701)
- Tyler Martinson (ORCID: https://orcid.org/0000-0001-6750-3954)
- Mallory O. Johnson (ORCID: https://orcid.org/0000-0003-0480-2804)
- Renessa S. Williams (ORCID: https://orcid.org/0000-0003-4814-1534)
- Monica Gandhi (ORCID: https://orcid.org/0000-0001-6674-5388)
- Kevin Sassaman (ORCID: https://orcid.org/0009-0003-4636-4045)
- Shivani Mahuvakar (ORCID: https://orcid.org/0009-0006-9406-4081)
Institutions
- University of Miami (US)
- City University of New York (US)
- University of California, San Francisco (US)
- SUNY Downstate Health Sciences University (US)
- Florida International University (US)
- San Diego State University (US)
- University of California System (US)
- Global Solutions for Infectious Diseases (US)
- Columbia University (US)
Publication Details
- Journal
- AIDS
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1097/qad.0000000000004288
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00