R-Spondin1 Regulates Fate of Enteric Neural Progenitors via Differential LGR4/5/6 Expression in Mice and Humans
LGR receptor expression therefore might represent a previously unknown mechanism influencing the fate decision of ENS progenitor cells between proliferation and neuronal differentiation. Thus, our study is essential for our understanding of regenerative aspects of the postnatal ENS in health and disease.
Authors
- Simon Scherer (ORCID: https://orcid.org/0000-0002-6404-6919)
- Bernhard Hirt (ORCID: https://orcid.org/0000-0002-6018-7191)
- Peter H. Neckel (ORCID: https://orcid.org/0000-0003-1976-0512)
- Jörg Fuchs (ORCID: https://orcid.org/0000-0003-4171-5371)
- Melanie Scharr (ORCID: https://orcid.org/0009-0002-6246-0267)
Institutions
- University Children's Hospital Tübingen (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101642
- Primary Topic
- Congenital gastrointestinal and neural anomalies
- Type
- article
- Field-Weighted Citation Impact
- 0.00