A Myeloid Lineage Signifying Anti-tumor Necrosis Factor Resistance in Crohn’s Disease
Increased levels of myeloid lineage expressing CD33<sup>+</sup>HLA-DR<sup>+</sup>CD11c<sup>+</sup>SIRPα<sup>+</sup> cells in the intestinal mucosa negatively impact epithelial cell function, possibly explaining one mechanism for anti-TNF resistance. The abundance of mucosal SIRPα<sup>+</sup> cells should be further explored as a biomarker and therapeutic target.
Authors
- Sushma Chowdary Maddipatla
- Vasantha L. Kolachala (ORCID: https://orcid.org/0009-0005-6919-3765)
- Duke Geem (ORCID: https://orcid.org/0000-0001-9270-2103)
- Ranjit Pelia
- Venkatarao Koti
- Yeonjoo Hwang (ORCID: https://orcid.org/0000-0002-3000-4710)
- Murugadas Anbazhagan (ORCID: https://orcid.org/0000-0002-2794-981X)
- Cary G. Sauer
- Garima Sharma (ORCID: https://orcid.org/0000-0001-8417-3926)
- Shanta Murthy
- Raghavan Chinnadurai (ORCID: https://orcid.org/0000-0001-9272-4070)
- Subra Kugathasan
- Jason D. Matthews
- Sachith Munasinghe
- Irina Geiculescu
- Barbara J Niklinsa-Schirtz
- Kodhai Duraiarasan
Institutions
- Mercer University (US)
- Emory University (US)
- Children's Healthcare of Atlanta (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101636
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00